IndraLab

Statements

MYSM1 increases the amount of ESR. 4 / 4
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"The results showed that knockdown of MYSM1 decreased ERα protein level, whereas ERα mRNA expression had no significant change (Fig. 3A,B)."
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"The results revealed that loss of MYSM1 dramatically decreased ERα and c-Myc protein expression, accompanied by a reduction in the Ki67 index in xenograft tumor tissue (Figs."
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"The data demonstrated MYSM1 knockdown significantly suppressed the transcription of endogenous ERα regulated genes, including c-Myc, CCND1, VEGF, GREB1, TFF1, E2F1, FOXC1 (Figs."
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"Unexpectedly, in western blot experiments as shown in Fig. 2E,F, we observed that ectopic expression of MYSM1 increased ERα protein expression, while knockdown of MYSM1 reduced ERα protein level."
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