IndraLab

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"MYSM1 initiates the expression of necroptosis-related genes via promoting the transcription factor function of STAT1."
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"Additionally, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1.Conclusion: This study illustrated a MYSM1-STAT1 axis in regulating myocardial I/R injury and identified MYSM1 as a pharmacological target for myocardial I/R injury."
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"Notably, STAT1 knockdown (STAT1-KD, Figure S6J) reversed MYSM1-mediated up-regulation of Mlkl and Ripk3 mRNAs (Figure 7J-K), confirming that MYSM1 transcriptionally increased the expression of necroptosis-related genes via STAT1."
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"In summary, these results showed that MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1."
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"Subsequently, MYSM1 initiated the expression of necroptosis-related genes by promoting the transcriptional activity of STAT1.The JAMMs family represents the sole zinc metalloprotease family, while the remaining DUB families consist of cysteine peptidases 10."
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"In addition, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1."
39897566