IndraLab

"Mechanistic studies revealed that MYSM1 activates Pax5 transcription by coordinating histone modifications and directing the recruitment of the transcription activators such as PU.1 to the Pax5 locus in B cells."

"MYSM1 stimulates transcription of miR-150 in B1a cells with c-Myc."

"The histone H2A deubiquitinase 2A-DUB or Mysm1/Kiaa1915 (Myb-like SWIRM and MPN domain containing1) is a nuclear protein of 828 amino acids containing a SWIRM domain, a SANT (SWI-SNF, ADA N-CoR, TFIIIB) domain with DNA-binding activity and a JAMN/MPN domain with intrinsic metalloprotease-like activity. xref In prostate cancer cells, Mysm1 activates transcription of androgen receptor-regulated genes as part of a co-regulatory complex with histone acetyltransferase p300/CBP-associated factor by coordinating histone acetylation and deubiquitination, and by destabilizing the association of linker histone H1 with nucleosomes. xref More recently, analysis of Mysm1 knockout mice revealed additional functions of the H2A-DUB in regulation of hematopoietic development as Mysm1 deficiency resulted in – among other abnormalities – severe depletion of B cells and T cells, anemia, and thrombocytosis. xref , xref Comparable with the pathophysiology of mice lacking PRC1 component Bmi1, xref postnatal lymphopenia in Mysm1-deficient mice correlated with a depletion of HSC likely resulting from activation of the DDR and uncontrolled production of reactive oxygen species (ROS). xref In murine skin, Mysm1 deficiency was associated with atrophy (present article and own unpublished observations) and malformation of the tail. xref "

"MYSM1 and USP16 activate transcription."

"MYSM1 deubiquitinates monoubiquitinated histone H2A and directs the recruitment of transcription factors to the promoter of target genes, including EBF1 and PU.1."

"MYSM1 as a deubiquitinase is involved in the deubiquitination of histone H2A to enhance gene transcription (Fiore et al, 2020)."

"MYSM1 excludes monoubiquitin from H2AK119ub1 and activates transcription in cooperation with histone acetylation [90]."

"As a deubiquitinase, MYSM1 stabilizes ERα protein through its MPN enzyme catalytic domain and is recruited with ERα at the promoters of E2-induced genes, thereby triggering transcription initiation and subsequent acceleration in cell proliferation and suppression of antiestrogen sensitivity."

"Additionally, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1.Conclusion: This study illustrated a MYSM1-STAT1 axis in regulating myocardial I/R injury and identified MYSM1 as a pharmacological target for myocardial I/R injury."

"In summary, these results showed that MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1."

"MYSM1 reverses the transcription repression of genes that are involved in hematopoietic stem cell homeostasis, hematopoiesis, and lymphocyte differentiation (94)."

"In addition, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1."

"An interesting area of future studies is to systemically identify MYSM1 partners and investigate the underlying molecular mechanisms for the selective gene targeting and transcription regulation by MYSM1."

"Further, we tested the possibility that MYSM1 may directly activate the transcription of Pax5 in mature B cells as well."