IndraLab

Statements

TP53 binds MYSM1. 11 / 11
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"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
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"At the Cdkn1a/ p21 locus, increased H3K27ac and H3K4me3 levels were also observed, but without increased p53 binding ( xref ), which indicates that MYSM1 can have an impact on H3K27ac levels independently of effects on p53 recruitment."
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"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 and PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a and p21."
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"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
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"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
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"Interaction between MYSM1 and p53 proteins was demonstrated in hematopoietic cell lines through co-immunoprecipitation (co-IP) [ xref ], and MYSM1 binding to the promoters of several p53 stress response genes was also reported, suggesting possible mechanisms for p53 regulation by MYSM1."
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"Given the recruitment of MYSM1 to genomic p53 binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
26768662
sparser
"Given the recruitment of MYSM1 to genomic p53-binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3/PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a/p21."
26768662
sparser
"The interaction of MYSM1 with p53 and their colocalization to p53-target gene promoters, in addition to p53 transcriptional signature activation in Mysm1 −/− HSPCs, suggest a role for MYSM1 in regulating p53 transcriptional activity."
26768662