IndraLab

Statements

MYSM1 binds TP53. 11 / 11
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"At the Cdkn1a/ p21 locus, increased H3K27ac and H3K4me3 levels were also observed, but without increased p53 binding ( xref ), which indicates that MYSM1 can have an impact on H3K27ac levels independently of effects on p53 recruitment."
26768662
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"Interaction between MYSM1 and p53 proteins was demonstrated in hematopoietic cell lines through co-immunoprecipitation (co-IP) [ xref ], and MYSM1 binding to the promoters of several p53 stress response genes was also reported, suggesting possible mechanisms for p53 regulation by MYSM1."
32344625
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"Co‐immunoprecipitation (CO‐IP) results indicated that Mysm1 interacts with p53 (Figure  xref )."
36414403
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"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
25710881
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"Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3 and PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a and p21."
26768662
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"Given the recruitment of MYSM1 to genomic p53 binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
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"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
26768662
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"We thus generated double-knockout mice to assess a potential genetic interaction between Mysm1 and p53 in hematopoiesis."
25710881
sparser
"Given the recruitment of MYSM1 to genomic p53-binding sites, we tested for interaction between MYSM1 and p53 proteins."
26768662
sparser
"MYSM1 therefore interacts with p53, either directly or more likely as part of a larger protein complex."
26768662
sparser
"The interaction of MYSM1 with p53 and their colocalization to p53-target gene promoters, in addition to p53 transcriptional signature activation in Mysm1 −/− HSPCs, suggest a role for MYSM1 in regulating p53 transcriptional activity."
26768662