
IndraLab
Statements
sparser
"Mechanistically, MYSM1 deubiquitinates and dephosphorylates RIPK2 S176 by recruiting PP2A. These findings offer unprecedented evidence of the MYSM1/PP2A/RIPK2 axis’s role in preserving cartilage homeostasis, indicating that targeting MYSM1 and downstream RIPK2 could be therapeutically beneficial for OA treatment."