IndraLab

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MYSM1 increases the amount of AR. 5 / 5
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"Recent work has shown that 2A-DUB acts as a co-activator of the androgen receptor (AR), modulating full activation of AR dependent gene expression through deubiquitination of H2A."
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"All this highlights the importance of MYSM1 in mammalian development and hematopoiesis, and the biomedical significance of understanding its functions.Monoubiquitinated histone H2A-K119ub was the first MYSM1 substrate to be discovered, and MYSM1 was shown to promote the expression of androgen receptor target genes in prostate cancer cell lines through H2A-K119ub deubiquitination ."
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"2A-DUB, a JAMM family DUB, was found to deubiquitinate H2A and positively regulate transcription of androgen receptor regulated genes in concert with the histone acetylase p and CAF complex [XREF_BIBR]."
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"27 In prostate cancer cells, Mysm1 activates transcription of androgen receptor regulated genes as part of a co and regulatory complex with histone acetyltransferase p300 and CBP associated factor by coordinating histone acetylation and deubiquitination, and by destabilizing the association of linker histone H1 with nucleosomes."
25613381
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"MYSM-1 can activate transcription of AR target genes via its involvement with p300 affecting histone acetylation and deubiquitination and binding of H1 to the nucleosome [XREF_BIBR]."
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