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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MYSM1 inhibits histone H2AK119ub. 2 / 2

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"At many of these loci , loss of MYSM1 resulted in increased binding of PRC1 complex proteins and elevated levels of histone H2AK119ub [ 20,30,32,33,34 ] , suggesting that MYSM1 antagonizes PRC1-mediated histone ubiquitination and transcriptional repression ."

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"MYSM1 was required for normal recruitment of transcription factors GATA2 and RUNX1 to the Gfi1 locus , while loss of MYSM1 resulted in increased recruitment of the PRC1 complex proteins RING1B and BMI1 and increased levels of histone H2AK119ub [ 34 ] ( Figure 2 ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...