IndraLab

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MYSM1 inhibits ATP. 3 / 3
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"These results suggest that Mysm1 exerts antidepressant effects by affecting ATP levels.Given that energy production in astrocytes is largely dependent on mitochondrial oxidative metabolism in response to neuronal activity, 20 we next tested whether Mysm1 knockdown in astrocytes could produce more ATP."
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"These results suggest that Mysm1 knockdown in astrocytes may upregulate TCA cycle process and mitochondrial oxidative phosphorylation levels to enhance mitochondrial function.Combined with the results that Mysm1 knockdown in astrocytes in vitro could produce more ATP, we explored whether Mysm1 knockdown in vivo could increase ATP in the interstitial space of the brain."
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"Here, we found that astrocytic Mysm1 knockdown in MHb cells promoted ATP production and induced antidepressant effects, which further confirmed the important role of astrocytes in energy modulation."
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