IndraLab

Statements

MYSM1 binds AR. 8 / 8
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"In this work we observed MYSM1-AR interactions which may be also responsible for the role of MYSM1 in androgen-responsive gene transcription."
31761786
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"Given the repression of AR transactivation by interaction of LCOR with AR [ xref ], we then concentrated on the interaction between MYSM1 and AR to dissect the functional significance of MYSM1 in AR signaling."
31761786
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"To verify the potential interaction between MYSM1 and AR, we carried out protein co-immunoprecipitation (Co-IP) assays with validated antibodies against MYSM1 and AR in C4-2 cells with or without siMYSM1 treatment."
31761786
sparser
"In summary, these findings demonstrate that MYSM1 can bind to AR and suppress the activation of Akt pathway in CRPC by downregulating phosphorylation levels of Akt, c-Raf and GSK-3β."
31761786
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"MYSM1 was able to bind to androgen receptor instead of increasing its expression and knockdown of MYSM1 resulted in activation of Akt/c-Raf/GSK-3β signaling."
31761786
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"MYSM1 interacts with AR and inhibits activation of Akt/c-Raf/GSK-3β signaling in prostate cancer."
31761786
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"Further mechanistic investigation indicated that MYSM1-AR interaction and Akt/c-Raf/GSK-3β pathway may underlie the role of MYSM1 in CRPC progression."
31761786
sparser
"As 2A-DUB may interact with AR via its SWIRM domain ( Metzger et al., 2005 ), recruitment of the complex might be AR dependent."
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