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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MYSM1 binds HELLS, PCNA, and RFC5. 1 / 1

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"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...