IndraLab

Statements

ESR inhibits MYSM1. 2 / 2
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"When cycloheximide (CHX) was applied at specified time points to inhibit protein synthesis, depletion of MYSM1 significantly accelerated ERα degradation and ectopic expression of wild-type MYSM1 plasmid (MYSM1-FL) ameliorated ERα degradation process (Fig. 3C,E)."
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"Compared with the full length of MYSM1, the lack of SWIRM domain had little effect on ERα-induced transactivation, while MYSM1-ΔSANT or MYSM1-ΔMPN dramatically reduced ERα action (Fig. 2C), indicating that the SANT or MPN domain is required for the co-activation function of MYSM1 on ERα-mediated transactivation.Indeed, ERα behaves in numerous biological processes through its target genes."
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