IndraLab

Statements

RIPK2 binds MYSM1. 5 / 5
| 3 2
sparser
"However, IL-1β treatment weakened the MYSM1-RIPK2 interaction (Fig. xref )."
39746943
reach
"In mouse primary chondrocytes, MYSM1 and RIPK2 interaction was confirmed via co-immunoprecipitation (Fig. 4h), and co-localization of these proteins was observed (Fig. 4i–j)."
39746943
reach
"We observed that PP2Ac interacted with RIPK2, but this interaction was abolished upon IL-1β treatment, and the binding of MYSM1 to RIPK2 was also disrupted under IL-1β stimulation (Fig. 6d, e)."
39746943
reach
"Our study reveals that the deubiquitinase MYSM1 interacts with and deubiquitinates RIPK2, recruiting PP2A to dephosphorylate RIPK2 and ultimately deactivate NF-κB and MAPK signaling pathways, thereby protecting chondrocytes from degeneration."
39746943
sparser
"One of these proteins, Ppp2ca (PP2Ac), functions as a serine/threonine protein phosphatase responsible for a significant portion of eukaryotic protein dephosphorylation events (Fig. xref ). xref The PP2A core enzyme comprises a scaffold subunit (A or PR65 subunit) and a catalytic subunit (C subunit, PP2Ac). xref We observed that PP2Ac interacted with RIPK2, but this interaction was abolished upon IL-1β treatment, and the binding of MYSM1 to RIPK2 was also disrupted under IL-1β stimulation (Fig. xref )."
39746943