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MYSM1 inhibits STING1. 2 / 2
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"Moreover, cGAMP induced the upregulation of IFN-β , IL-6 , and Cxcl10 mRNAs ( Figure 3 C), as well as IFN-β, IL-6, and TNF-α proteins ( Figure 3 D), and was significantly higher in BMDMs from Mysm1 −/[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, STING aggregation and STING-TBK1 interaction were significantly promoted in Mysm1 −/− mice, indicating that MYSM1 restricts STING activation by interacting with STING."
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