IndraLab

Statements

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"MYSM1 negatively regulates differentiation of human B cells to plasma cells."
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"Mysm1 knockdown in NSCs leads to NSC proliferation and early differentiation into neurons."
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"We demonstrated that MYSM1 intrinsically represses plasma cell differentiation and antibody production."
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"We revealed that MYSM1 intrinsically represses plasma cell differentiation and antibody production."
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"Mechanistic studies revealed that MYSM1 intrinsically represses plasma cell differentiation and antibody production by activating the transcription of Pax5, the repressors of plasma cell differentiation, in mature B cells."
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"Systemic loss of Mysm1 in Mysm1 fl/fl Tg.CreERT2 mice also impaired lymphoid lineage differentiation, resulting in a depletion of common lymphoid progenitors (CLPs), as well as mature B cells and CD8 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"MYSM1 intrinsically represses plasma cell differentiation."
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"Taken together, these data demonstrate that MYSM1 is an intrinsic repressor of plasma cell differentiation."
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"Thus, these data demonstrate that MYSM1 represses plasma cell differentiation, as well as Ig production by plasma cells."
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