IndraLab

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MYSM1 activates cell population proliferation. 12 / 12
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"Survival and proliferation of melanoma cells is supported by MYSM1."
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"Mysm1 -/- mice had enhanced HSC proliferation that led to a large dysfunctional LSK population."
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"On the other hand, our results also demonstrated that MYSM1 accelerates cell proliferation even in the absence of E2, suggesting that MYSM1 may also participate in regulating non-canonic ERα signaling pathway independent on E2 treatment to participate in promoting breast cancer process (Fig. 5A,B)."
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"These findings indicated that MYSM1 promotes cell proliferation and colony formation and attenuates SA-beta-Gal activation to repress senescence ."
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"In a separate study, Mysm1 -/- macrophages were confirmed to have elevated production of pro inflammatory cytokines in response to stimulation, as well as increased proliferation, increased apoptosis, and enhanced capacity to control melanoma tumor growth in vivo in mouse models [XREF_BIBR]."
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"As a deubiquitinase, MYSM1 stabilizes ERα protein through its MPN enzyme catalytic domain and is recruited with ERα at the promoters of E2-induced genes, thereby triggering transcription initiation and subsequent acceleration in cell proliferation and suppression of antiestrogen sensitivity."
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"Knockdown of MYSM1 promoted cell proliferation and suppressed senescence of CRPC cells under condition of androgen ablation."
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"Consistently, growth curve analysis showed that knockdown of MYSM1 inhibited cell proliferation, and ectopic expression of ERα partly rescued this condition (Figs."
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"Above all, the results indicate that MYSM1 promotes cell proliferation and G1-S phase transition in BCa, and the effect of MYSM1 on cell growth is partially related to ERα pathway.To test the functional of MYSM1 on BCa cell growth in vivo, MCF-7 cells infected with shMYSM1 or negative control lentivirus (shCtrl) were individually implanted subcutaneously into flank sides of 4-week-old female BALB/c nude mice (n = 7) armpit."
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"Meanwhile, MYSM1 knockout reduces the proliferation of osteoclast progenitor and the osteoclast resorption activity [130]."
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"MYSM1 depletion suppresses cell proliferation and increases antiestrogen sensitivity in BCa-derived cell lines."
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"Thus, MYSM1 enhances ERα action via histone and non-histone deubiquitination to promote cell proliferation and antiestrogen insensitivity in breast cancer progression."
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