IndraLab

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"Strong IL-15 receptor stimulation by IL-2 pre-ligated to an anti-IL-2 antibody, or SOCS-3 deficiency, partially restores homeostasis in Id2 deficient NK cells.In support of the role of ID2 in NK cell maturation, deficiency of MYSM1, which mediates the recruitment of E4BP4 to the Id2 locus, leads to defects in NK cell maturation, but not NK lineage specification or commitment (23)."