IndraLab

Statements

MYSM1 inhibits MAPK cascade. 5 / 5
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"MYSM1 deletion activated NF-κB and MAPK signaling, significantly promoting OA development and exacerbating cartilage degeneration."
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"MYSM1 attenuates NF-kappaB and MAPK signaling pathways in chondrocytes."
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"These results indicate that MYSM1 deactivates NF-κB and MAPK signaling pathways, thereby protecting mouse chondrocytes against inflammation."
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"Mechanistically, MYSM1 inhibited the NF-kappaB and MAPK signaling pathways."
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"Our findings demonstrate that Mysm1 overexpression deactivates NF-κB and MAPK signaling pathways, whereas Mysm1 knockdown significantly activates these pathways in mouse chondrocytes."
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