IndraLab

Statements

MYSM1 inhibits DNA Damage. 3 / 3
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"Mechanistically, defective development of Mysm1-deficient mice correlated with altered gene transcription, increased apoptosis, and increased DNA damage in a variety of tissues, and was largely rescued by concomitant deletion of tumor suppressor p53 [38,42,43,44]."
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"MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks."
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"Loss of MYSM1 results in increased DNA damage signaling in lymphocytes and nonlymphoid cells, but its function in cellular responses to DNA injury has not been characterized."
38065233