IndraLab

Statements

STING1 binds MYSM1. 22 / 22
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"In transfected HEK293T cells, MYSM1 interacted with STING, but not with cGAS, TBK1, or IRF3 ( Figure S3 A)."
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"In HSV-1-infected THP-1 differentiated macrophages, endogenous MYSM1 interacted strongly with STING at 2 h post-infection ( Figure 3 E)."
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"The domains required for MYSM1-STING interaction were determined by analyzing mutated forms of STING and MYSM1 ( Figures S4 A and S4B)."
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"MYSM1 interacted with STING and STING(1–190) but not with STING(191–379) ( Figure S4 C)."
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"STING interacted strongly with MYSM1 and weakly with MYSM1(ΔSANT) and MYSM1(ΔMPN), but failed to interact with MYSM1(ΔSWIRM) ( Figure S4 D)."
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"Additionally, the deubiquitinating enzyme MYSM1 interacts with and modifies STING, preventing downstream signaling and offering new therapeutic avenues (69)."
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"These results demonstrate that MYSM1 interacts with STING through the SWIRM domain and specifically cleaves STING K63-linked ubiquitination on Lys150 through the MPN domain."
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"MYSM1 subsequently interacts with STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling ( xref )."
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"MYSM1 binds to STING and inhibits the cGAS-STING signaling pathway [169]."
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"MYSM1 interacts with the STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling pathway ( xref )."
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"MYSM1 interacts with STING and cleaves the ubiquitination of the STING at Lys63 to inhibit cGAS-STING signaling ( xref ) ( xref )."
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"We have shown that the SWIRM domain is necessary for MYSM1 interaction with STING, and the MPN domain is necessary for STING deubiquitination."
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"MYSM1 binds to STING, removes its K63-linked ubiquitination, inhibits STING aggregation, and suppresses the formation of type I IFNs and pro-inflammatory cytokines, thereby restricting the cGAS-STING [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"DNA virus infection induces interaction between MYSM1 (Myb-like, SWIRM, and MPN domains 1) and STING to suppress innate immune responses [ xref ]."
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"MYSM1 associates with STING and removes its K63-linked ubiquitination, thereby inhibiting STING signaling xref ."
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"MYSM1 subsequently interacts with STING and cleaves K63-linked ubiquitinated STING to suppress cGAS–STING signaling.[ xref ]In addition, the oncogenes E7 from human papillomavirus 18 and E1A from adenovirus inhibit the cGAS–STING signaling pathway.[ xref ]The phase separation of cGAS–DNA is essential for the antiviral innate immune response."
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"Activated MYSM1 binds to STING and removes its K63-linked polyubiquitination, repressing the synthesis of type I IFNs and pro-inflammatory cytokines, including IFN-β, IFN-stimulated gene 56 (ISG56), i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"MYSM1 binds to STING and inhibits the cGAS-STING signaling pathway [ xref ]."
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