IndraLab

Statements

STING1 binds MYSM1. 16 / 20
4 | 2 14
sparser
"In transfected HEK293T cells, MYSM1 interacted with STING, but not with cGAS, TBK1, or IRF3 ( Figure S3 A)."
33086059
sparser
"In HSV-1-infected THP-1 differentiated macrophages, endogenous MYSM1 interacted strongly with STING at 2 h post-infection ( Figure 3 E)."
33086059
sparser
"The domains required for MYSM1-STING interaction were determined by analyzing mutated forms of STING and MYSM1 ( Figures S4 A and S4B)."
33086059
sparser
"MYSM1 interacted with STING and STING(1–190) but not with STING(191–379) ( Figure S4 C)."
33086059
sparser
"STING interacted strongly with MYSM1 and weakly with MYSM1(ΔSANT) and MYSM1(ΔMPN), but failed to interact with MYSM1(ΔSWIRM) ( Figure S4 D)."
33086059
reach
"Additionally, the deubiquitinating enzyme MYSM1 interacts with and modifies STING, preventing downstream signaling and offering new therapeutic avenues (69)."
40028324
sparser
"These results demonstrate that MYSM1 interacts with STING through the SWIRM domain and specifically cleaves STING K63-linked ubiquitination on Lys150 through the MPN domain."
33086059
sparser
"MYSM1 subsequently interacts with STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling ( xref )."
36189363
reach
"MYSM1 binds to STING and inhibits the cGAS-STING signaling pathway [169]."
36359370
sparser
"DNA virus infection induces interaction between MYSM1 (Myb-like, SWIRM, and MPN domains 1) and STING to suppress innate immune responses [ xref ]."
38005886
sparser
"Activated MYSM1 binds to STING and removes its K63-linked polyubiquitination, repressing the synthesis of type I IFNs and pro-inflammatory cytokines, including IFN-β, IFN-stimulated gene 56 (ISG56), i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33086059
sparser
"MYSM1 binds to STING and inhibits the cGAS-STING signaling pathway [ xref ]."
36359370
sparser
"MYSM1 interacts with the STING and cleaves STING K63-linked ubiquitination to suppress cGAS-STING signaling pathway ( xref )."
33643304
sparser
"MYSM1 interacts with STING and cleaves the ubiquitination of the STING at Lys63 to inhibit cGAS-STING signaling ( xref ) ( xref )."
36172373
sparser
"We have shown that the SWIRM domain is necessary for MYSM1 interaction with STING, and the MPN domain is necessary for STING deubiquitination."
33086059
sparser
"MYSM1 binds to STING, removes its K63-linked ubiquitination, inhibits STING aggregation, and suppresses the formation of type I IFNs and pro-inflammatory cytokines, thereby restricting the cGAS-STING [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33086059