IndraLab

Statements

MYSM1 deubiquitinates RIPK2. 3 / 3
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reach
"Mechanistically, MYSM1 deubiquitinates and dephosphorylates RIPK2 by recruiting PP2A."
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reach
"These results suggest that the phosphorylation of RIPK2 is essential for RIPK2 ubiquitination, and MYSM1 reduces the phosphorylation and ubiquitination of RIPK2 with the assistance of PP2A (Fig. 7)."
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reach
"Our study reveals that the deubiquitinase MYSM1 interacts with and deubiquitinates RIPK2, recruiting PP2A to dephosphorylate RIPK2 and ultimately deactivate NF-κB and MAPK signaling pathways, thereby protecting chondrocytes from degeneration."
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