IndraLab

Statements

MYSM1 activates STAT1. 5 / 5
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"MYSM1 was found to enhance the protein stability of STAT1, which correspondingly resulted in an increased phosphorylation level of STAT1."
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"Taken together, these results suggested that MYSM1 promotes STAT1 stability by cleaving the polyubiquitin chains on K379 residue of STAT1 (Figure 6M)."
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"In summary, these results showed that MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1."
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"Mechanistically, MYSM1 promotes the stability of STAT1 by cleaving polyubiquitin chains from the K379 residue of STAT1."
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"In addition, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1."
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