IndraLab

Statements

MYSM1 activates TP53. 3 / 3
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reach
"Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions.To compare the location of the genomic binding sites of MYSM1 and cMYC, we consolidated the ChIP‐Seq datasets for cMYC and its dimerization partner MAX from multipotent haematopoietic progenitor cells HPC7 12 , 13 with the MYSM1 ChIP‐Seq acquired in our recent work in a B cell progenitor cell line Ba/F3."
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"We recently demonstrated that all developmental and hematopoietic phenotypes of Mysm1 deficiency are p53 mediated and rescued in the Mysm1 -/- p53 -/- mouse model."
26768662
reach
"Furthermore, we identify potential mediators of p53 dependent but PUMA independent Mysm1 -/- hematopoietic deficiency phenotypes."
26768662