IndraLab

Statements

MYSM1 inhibits Mice. 4 / 4
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"Mice with Mysm1 knockdown by crossing Mysm1 floxed mice with Nestin-Cre mice exhibited abnormal brain development with microcephaly."
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"Interestingly, type I IFN, pro-inflammatory cytokines, TBK1, and IRF3 induced by DNA sensing were downregulated by MYSM1, upregulated by sh- Mysm1 , and enhanced in Mysm1 −/− mice."
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"Increased MYSM1 can decrease type I IFN, IL-6, and other inflammatory cytokines in SLE mice (86)."
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"Moreover, cGAMP induced the upregulation of IFN-β , IL-6 , and Cxcl10 mRNAs ( Figure 3 C), as well as IFN-β, IL-6, and TNF-α proteins ( Figure 3 D), and was significantly higher in BMDMs from Mysm1 −/[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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