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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MYSM1 decreases the amount of TP53. 2 / 2

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"Our work demonstrates that MYSM1 represses p53 stress response gene expression by localizing to p53 binding sites within Bbc3 and PUMA and Cdkn1a and p21 promoters and antagonizing local histone modification (H3K27ac and H3K4me3) and p53 recruitment (XREF_FIG)."

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"IRF2 and IRF8 reduction in Mysm1 -/- HSCs enhances p53 levels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...