IndraLab

Statements

MYSM1 binds KAT2B. 13 / 14
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"2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones."
17707232
sparser
"Interestingly, 2A-DUB associates with PCAF, a histone acetyltransferase subunit of the hSAGA complex."
21513801
biogrid
No evidence text available
17707232
reach
"Correlating with the recruitment of 2A-DUB and p/CAF, a clear decrease of uH2A levels and a coincidently increased level of acetylated H3 (Ac-H3) were observed upon DHT treatment in LNCaP cells, sugge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
biogrid
No evidence text available
17707232
sparser
"2A-DUB interacts with PCAF and is required for full activation of androgen receptor-dependent genes (Zhu et al., xref )."
22649782
reach
"Displacement of linker histones, which is facilitated by their phosphorylation, is generally linked to gene activation but has also been linked to repression in a few instances, coincident with the co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
reach
"2A-DUB interacts with PCAF and is required for full activation of androgen receptor dependent genes."
22649782
sparser
"Unexpectedly, specific interactions between p/CAF and 2A-DUB, as components of a protein complex, seem to coordinate histone ubiquitination and acetylation."
17707232
sparser
"Coimmunoprecipitation assays further confirmed a specific interaction of 2A-DUB with p/CAF, as well as interactions with R NA- b inding m otif protein 10 (RBM10) and t hyroid hormone r eceptor ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17707232
sparser
"The HAT P/CAF physically interacts with the DUB Mysm1 ( xref ); however, whether DUBs play a role in the regulation of HAT stability is unclear."
28611184
sparser
"2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones."
17707232
sparser
"The interacting partners 2A-DUB and PCAF, are recruited to the promoter region, remove the uH2A repressive mark and facilitate the dissociation of linker proteins, creating an open chromatin environment."
20974139