IndraLab

Statements

OTUD5 is modified
34 | 1 17 2
OTUD5 is phosphorylated.
34 | 16 2
OTUD5 is phosphorylated. 10 / 14
| 13 1
sparser
"Consistent with previous NMR studies on the isoform 1 of DUBA ( xref ), the chemical shifts of only a few residues near S177, including G174, Y175 and E178, are perturbed in the phosphorylated DUBA."
30232733
sparser
"With genetic rescue experiments we demonstrate that DUBA phosphorylation and catalytic activity are crucial in vivo for DUBA function in spermatogenesis."
27518434
sparser
"The crystal structure of the catalytic domain of the phosphorylated DUBA (p-DUBA) conjugated to ubiquitin-aldehyde revealed that the interactions between the phosphate group and the two positively charged residues, R272 and K273, in the α6 helix lead to the enclosure of the C-terminal tail of ubiquitin ( xref ). xref NMR studies show that phosphorylation induces minimal structural changes in the apo state of DUBA, xref raising the question of whether modulation of conformational dynamics plays a role in DUBA activation."
33417762
sparser
"The phosphorylated DUBA displays essentially the same predicted secondary structure, which is in good agreement with the crystal structures of both non-phosphorylated DUBA in free form (PDB ID: 3PFY) and phosphorylated DUBA covalently linked to ubiquitin aldehyde (PDB ID: 3TMP)."
30232733
sparser
"The crystal structure of the Ub-aldehyde complex with phosphorylated OTUD5 reveals a remarkable interaction between the phosphorylated Ser177 of OTUD5 and the guanidinium moiety of Arg74 of the bound ubiquitin showing that the phosphorylation is essential for the DUB activity [ xref ]."
32512887
sparser
"Therefore, modulating OTUD5 phosphorylation may be a promising strategy for tumor treatment."
32826889
sparser
"Moreover, phosphorylated OTUD5 was more efficient than wild-type OTUD5 in removing the ubiquitin chain of TRIM25 (Fig.  xref , lane 2 versus lane 3)."
32826889
sparser
"This is somewhat reminiscent of the activation mechanism of DUBA/OTUD5 by phosphorylation, which also depends on a UIM, yet in the case of DUBA phosphorylation activates a relatively less chain-specific DUB ( xref )."
29395066
sparser
"Consistently, our work indicated that phosphorylated OTUD5 is particularly efficient at cleaving the ubiquitin chains of TRIM25."
32826889
sparser
"A recent study using NMR and enzymatic kinetics of different forms of OTUD5 confirmed that only the phosphorylated OTUD5 is important for the activity [ xref ]."
32512887
OTUD5 is phosphorylated on S177. 8 / 8
4 | 3 1
hprd
No evidence text available
20068231
hprd
No evidence text available
18452278
hprd
No evidence text available
18669648
sparser
"Phosphorylation of OTUD5 at Ser177 is critical to the enzyme activity of OTUD526.in our results, the most important of kinase-target networks related primarily to the kinases PLK1, ATM, PIK3CA, CDK5 and CHEK1."
32655987
rlimsp
"Here we show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme."
22245969
sparser
"Phosphorylation of OTUD5 (also known as DUBA) at Ser177 is both necessary and sufficient to activate the enzyme which is a negative regulator of type I interferon [ xref ]."
32512887
hprd
No evidence text available
15302935
sparser
"In the OTU family, phosphorylation of DUBA (OTUD5) on S177 results in activation of its enzymatic activity ( xref )."
25904330
OTUD5 is phosphorylated on S165. 6 / 6
6 |
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
hprd
No evidence text available
19415658
hprd
No evidence text available
19664994
hprd
No evidence text available
19413330
hprd
No evidence text available
19651622
OTUD5 is phosphorylated on S64. 6 / 6
6 |
hprd
No evidence text available
20230923
hprd
No evidence text available
17924679
hprd
No evidence text available
18669648
hprd
No evidence text available
19651622
hprd
No evidence text available
18691976
hprd
No evidence text available
20068231
OTUD5 is phosphorylated on T507. 5 / 5
5 |
hprd
No evidence text available
18669648
hprd
No evidence text available
19664995
hprd
No evidence text available
20068231
hprd
No evidence text available
18691976
hprd
No evidence text available
19413330
OTUD5 is phosphorylated on Y175. 5 / 5
5 |
hprd
No evidence text available
18669648
hprd
No evidence text available
19651622
hprd
No evidence text available
19415658
hprd
No evidence text available
19413330
hprd
No evidence text available
20068231
OTUD5 is phosphorylated on S508. 3 / 3
3 |
hprd
No evidence text available
19664995
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
OTUD5 is phosphorylated on S452. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
OTUD5 is phosphorylated on S512. 1 / 1
1 |
hprd
No evidence text available
18669648
OTUD5 is phosphorylated on T449. 1 / 1
1 |
hprd
No evidence text available
18669648
OTUD5 is phosphorylated on Y181. 1 / 1
1 |
hprd
No evidence text available
18669648
OTUD5 is methylated.
| 1
OTUD5 is methylated. 1 / 1
| 1
sparser
"Our analysis suggested that although OTUD5 is methylated in cervical cancer, its coexpressed genes may affect the progression of cervical cancer by regulating methylation."
32655987
OTUD5 is produced.
| 1
OTUD5 is produced. 1 / 1
| 1
trips
"Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98."
25499082
OTUD5 affects TP53
9 1 | 20 12
OTUD5 binds TP53.
9 | 6 11
TP53 binds OTUD5. 10 / 27
9 | 6 9
sparser
"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
reach
"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
sparser
"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
biogrid
No evidence text available
19615732
sparser
"Furthermore, we sought to determine whether endogenous p53 interacts with endogenous OTUD5."
24143256
biogrid
No evidence text available
24143256
biogrid
No evidence text available
25499082
reach
"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
reach
"Next, the interaction between p53 and OTUD5 in mammalian cells was verified by co-immunoprecipitation (Co-IP) assay."
24143256
biogrid
No evidence text available
24143256
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
GST binds TP53 and OTUD5. 1 / 1
| 1
sparser
"As shown in xref , GST-p53 but not GST interacted with the full-length OTUD5."
24143256
OTUD5 deubiquitinates TP53.
1 | 7
OTUD5 deubiquitinates TP53. 8 / 8
1 | 7
reach
"In this study, we provide new evidences that OTUD5 can also function to deubiquitinate and stabilize p53."
24143256
ubibrowser
"Review"
28801249
reach
"We show that (1) OTUD5 is a novel p53 interacting protein; (2) OTUD5 deubiquitinates p53, leading to the stabilization of p53; (3) OTUD5 can help in the stabilization and activation of p53 in response to DNA damage; (4) OTUD5 is required for p53 induced apoptosis in response to DNA damage."
24143256
reach
"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay."
24143256
reach
"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay and found thatMDM2 can not be deubiquitinated by OTUD5 (XREF_FIG)."
24143256
reach
"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."
29142505
reach
"Overall, OTUD5 deubiquitinates p53, leading to the stabilization of p53."
24143256
reach
"Another DUB, OTUD5, interacts and deubiquitylates p53 in response to DNA damage stress."
27516771
OTUD5 activates TP53.
| 6
OTUD5 activates TP53. 6 / 8
| 6
reach
"Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress."
25499082
reach
"Overexpression of OTUD5 efficiently enhanced the activation of both PDCD5 and p53."
25499082
reach
"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
32248621
reach
"The function of OTUD5 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent apoptosis in response to DNA damage stress."
24143256
reach
"OTU deubiquitinase (OTUD5) binds to PDCD5inresponseto etoposide treatment and effectively mediates the sequential activation of both PDCD5 and P53."
27398268
reach
"To this end, 1mug of p53 and increasing amounts of Flag-OTUD5 were cotransfected into H1299 cells."
24143256
OTUD5 inhibits TP53.
| 1
OTUD5 inhibits TP53. 1 / 3
| 1
sparser
"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
| PMC
OTUD5 decreases the amount of TP53.
| 1
OTUD5 decreases the amount of TP53. 1 / 2
| 1
reach
"Using shRNA mediated depletion of OTUD5 in U2OS cells caused marked decrease of p53 protein levels with no effect on p53 mRNA levels (XREF_FIG)."
24143256
OTUD5 affects TRAF3
1 2 1 | 29 7
OTUD5 deubiquitinates TRAF3.
1 | 14
OTUD5 deubiquitinates TRAF3. 10 / 14
| 14
reach
"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKɛ [38]."
23333767
reach
"Two close relatives of DUBA, OTUB1 and OTUB2, were shown to reduce TRAF3 ubiquitination coupled with decreased anti-viral signaling responses in Sendai virus infected HEK 293T cells."
22017431
reach
"DUBA deubiquitinates TRAF3 to downregulate its interaction with TBK1 and consequent activation of IRF-3 (Kayagaki et al., 2007)."
27178468
reach
"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3."
24622840
reach
"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."
21625535
reach
"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3 (Kayagaki et al., 2007; Wang et al., 2011)."
24622840
reach
"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKe [38] ."
23333767
reach
"DUBA deubiquitinates TRAF3 to down-regulate its interaction with TBK1 and consequent activation of IRF-3."
27178468
reach
"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKepsilon XREF_BIBR."
23333767
reach
"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
22017431
OTUD5 deubiquitinates TRAF3 on lysine. 1 / 1
1 |
biopax:reactome
No evidence text available
OTUD5 binds TRAF3.
2 1 | 5 6
TRAF3 binds OTUD5. 10 / 14
2 1 | 4 6
sparser
"DUBA not only interacts with TRAF3 and inhibits TRAF3 ubiquitination, but also interrupts the interaction between TRAF3 and TBK1."
32850399
reach
"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."
21625535
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
reach
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197]."
| DOI
biogrid
No evidence text available
17991829
sparser
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197] ."
| DOI
sparser
"Interference with the Lys63-linked auto-ubiquitination of TRAF3 is performed by DUBA (OTUD5), which interacts with TRAF3 [50]."
28625850
reach
"Interestingly, DUBA physically interacts with TRAF3 and inhibits the self ubiquitylation of TRAF3 (XREF_FIG)."
18535581
sparser
"An unambiguous identification of DUBA-interacting proteins suggests that DUBA interacts with TRAF3, whose K63-linked polyubiquitination is required for TLR-and RLR-mediated signaling."
32215003
sparser
"Fig. 4 shows the TRAF3-DUBA interaction model that we obtained by PRISM [36], [37], [38], in which the concave crevice on TRAF-C of TRAF3 is in contact with DUBA."
27208423
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
OTUD5 inhibits TRAF3.
| 5 1
OTUD5 inhibits TRAF3. 6 / 6
| 5 1
reach
"TRAF3 are inhibited by DUBA, OTUB1 and UCHL1 that specilally remove TRAF3 K63‐linked ubiquitination."
28744851
reach
"Structural data suggest that 1) Toll and IL-1R (TIR) domain containing regulators (BCAP, SIGIRR, and ST2) interfere with TIR domain signalosome formation; 2) major deubiquitinases such as A20, CYLD, and DUBA prevent association of TRAF6 and TRAF3 with their partners, inaddition to removing K63 linked ubiquitin chains that serve as a docking platform for downstream effectors; 3) alternative downstream pathways of TLRs also restrict signaling by competing to bind common partners through shared binding sites."
26276688
reach
"TRAF3 activation can in turn be negated by DUBA, a DUB specifically binding TRAF3 and deconjugating its K63 chains [32] ."
22964110
reach
"TRAF3 activation is negatively regulated by SOCS3 and DUBA."
25309543
reach
"TRAF3 activation is inhibited by SOCS3 and DUBA and TRAF 6 is targeted by numerous inhibitors including A20, USP4, CYLD, and others [73,74]."
| PMC
sparser
"TRAF3 are inhibited by DUBA, OTUB1 and UCHL1 that specilally remove TRAF3 K63‐linked ubiquitination."
28744851
OTUD5 ubiquitinates TRAF3.
| 2
OTUD5 leads to the ubiquitination of TRAF3. 2 / 2
| 2
reach
"Other DUBs that target the RIG-I and MDA5 pathway include CYLD and DUBA which target RIG-I and TRAF3 ubiquitination respectively (XREF_FIG)."
22435550
reach
"In addition to USP21, A20, and CYLD, DUBA has been shown to down-regulate antiviral signaling by deubiquitinating TRAF3."
24493797
OTUD5 activates TRAF3.
| 2
OTUD5 activates ubiquitinated TRAF3. 1 / 1
| 1
reach
"Expression of DUBA cleaves Lys63-linked ubiquitin chains on TRAF3 and depletion of DUBA increases ubiquitinated TRAF3."
18703349
OTUD5 activates TRAF3. 1 / 1
| 1
reach
"Moreover, the adaptor proteins TRAF3 and TRAF6 are targeted by the cellular proteins DUBA and A20 XREF_BIBR, XREF_BIBR, and TBK1 is sequestered by SIKE XREF_BIBR."
21677781
OTUD5 increases the amount of TRAF3.
| 1
OTUD5 increases the amount of TRAF3. 1 / 1
| 1
reach
"DUBA cleaves the K63-linked polyubiquitin chains of TRAF3 and depletion of DUBA increases the level of ubiquinated TRAF3 both in steady-state cells and in ligands-stimulated cells."
32215003
TP53 affects OTUD5
9 | 6 11
TP53 binds OTUD5. 10 / 27
9 | 6 9
sparser
"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
reach
"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
sparser
"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
biogrid
No evidence text available
19615732
sparser
"Furthermore, we sought to determine whether endogenous p53 interacts with endogenous OTUD5."
24143256
biogrid
No evidence text available
24143256
biogrid
No evidence text available
25499082
reach
"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
reach
"Next, the interaction between p53 and OTUD5 in mammalian cells was verified by co-immunoprecipitation (Co-IP) assay."
24143256
biogrid
No evidence text available
24143256
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
GST binds TP53 and OTUD5. 1 / 1
| 1
sparser
"As shown in xref , GST-p53 but not GST interacted with the full-length OTUD5."
24143256
OTUD5 affects PDCD5
5 1 | 6 5
OTUD5 binds PDCD5.
5 | 3
OTUD5 binds PDCD5. 7 / 7
5 | 2
biogrid
No evidence text available
25499082
sparser
"Moreover, OTUD5 interacts with PDCD5 in response to etoposides, which is a prerequisite for the stabilization and activation of p53 xref , xref ."
32826889
biogrid
No evidence text available
25499082
sparser
"Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98."
25499082
biogrid
No evidence text available
25499082
biogrid
No evidence text available
25499082
biogrid
No evidence text available
25499082
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
OTUD5 activates PDCD5.
| 4 1
OTUD5 activates PDCD5. 5 / 8
| 4 1
sparser
"Studies have shown that OTUD5 can activate the programmed cell death 5 (PDCD5, a tumor suppressor; Park et al., xref )."
| PMC
reach
"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
32248621
reach
"Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress."
25499082
reach
"OTU deubiquitinase (OTUD5) binds to PDCD5inresponseto etoposide treatment and effectively mediates the sequential activation of both PDCD5 and P53."
27398268
reach
"Overexpression of OTUD5 efficiently enhanced the activation of both PDCD5 and p53."
25499082
OTUD5 deubiquitinates PDCD5.
1 | 2
OTUD5 deubiquitinates PDCD5. 1 / 1
1 |
ubibrowser
"Conversely, PDCD5 knockdown greatly attenuated the effect of OTUD5 on p53 activation."
25499082
OTUD5 deubiquitinates PDCD5 on K97. 1 / 1
| 1
reach
"OTUD5 thus deubiquitinates PDCD5 at Lys97 and Lys98 subsequently regulating p53 levels."
29479529
OTUD5 deubiquitinates PDCD5 on K98. 1 / 1
| 1
reach
"OTUD5 thus deubiquitinates PDCD5 at Lys97 and Lys98 subsequently regulating p53 levels."
29479529
OTUD5 inhibits PDCD5.
| 1
OTUD5 inhibits PDCD5. 1 / 1
| 1
sparser
"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
| PMC
OTUD5 affects NP
| 17
OTUD5 binds NP. 10 / 17
| 17
sparser
"The data were subsequently group fit with a common exchange rate for residues that satisfy χ 2 group /χ 2 invididual < 2.0. xref Group fitting yielded k ex = 4954 ± 82 s −1 for p-DUBA ( xref ). np-DUBA undergoes a similar conformational exchange process with the exchange rate of 5750 ± 110 s −1 ( xref )."
33417762
sparser
"A network of dynamic residues underlies the synchronized motions observed in both p-DUBA and np-DUBA and explains the similarity in the global conformational dynamics in these two forms."
33417762
sparser
"In the enzyme-substrate complex formed from np-DUBA, the α1 helix either cannot adopt a closed conformation or fluctuates rapidly between open and closed conformations."
33417762
sparser
"Motions in the apo state of enzymes can facilitate substrate binding by enabling transitions into to a binding competent state xref , xref and can also regulate the catalytic cycle by allowing access to conformational states conducive for catalytic turnover. xref – xref The low activity of np-DUBA likely results from its inability to form a highly productive enzyme-substrate complex rather than low binding affinity to substrates because only 3-fold enhancement in the affinity to the fluorogenic ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) substrate was observed upon phosphorylation, whereas the enhancement in k cat is 300-fold. xref We can speculate that an important feature of the productive enzyme-substrate complex is that the α1 helix can adopt a closed conformation, as defined by the crystal structure of p-DUBA in the ubiquitin-bound state. xref The only conformer in np-DUBA lies between the a and b conformers in terms of structural characteristics according to the relative positions of cross-peaks. xref This observation indicates that at least in the free state, the α1 helix in np-DUBA adopts a more open conformation than the a conformer in p-DUBA."
33417762
sparser
"Broadening of NMR spectral lines and the resulting low signal intensities are signatures of conformational exchanges on the μs-ms scales. xref Among ~ 120 cross-peaks detectable in the 15 N TROSY spectra of p-DUBA, many display broad 1 H lines, whereas the 15 N transverse relaxation rates of majority of the resonances are consistent with the molecular weight. xref , xref TROSY spectra of nonphosphorylated DUBA (np-DUBA) display similar features."
33417762
sparser
"The higher R 2,eff could result from motions that are too fast to yield relaxation dispersion and/or higher solvent exchange rate in np-DUBA."
33417762
sparser
"E200 is spatially close to the α1-α2 loop and similarly show decreased R ex in the p-DUBA compared to np-DUBA."
33417762
sparser
"Only one residue, E200, displays more than 2-fold difference in the R ex between p-DUBA and np-DUBA."
33417762
sparser
"In regions outside the N-terminal segment, p-DUBA and np-DUBA are highly similar ( xref )."
33417762
sparser
"Differences in the dynamics of p-DUBA and np-DUBA."
33417762
TRAF3 affects OTUD5
2 1 | 6 6
TRAF3 binds OTUD5.
2 1 | 5 6
TRAF3 binds OTUD5. 10 / 14
2 1 | 4 6
sparser
"DUBA not only interacts with TRAF3 and inhibits TRAF3 ubiquitination, but also interrupts the interaction between TRAF3 and TBK1."
32850399
reach
"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."
21625535
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
reach
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197]."
| DOI
biogrid
No evidence text available
17991829
sparser
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197] ."
| DOI
sparser
"Interference with the Lys63-linked auto-ubiquitination of TRAF3 is performed by DUBA (OTUD5), which interacts with TRAF3 [50]."
28625850
reach
"Interestingly, DUBA physically interacts with TRAF3 and inhibits the self ubiquitylation of TRAF3 (XREF_FIG)."
18535581
sparser
"An unambiguous identification of DUBA-interacting proteins suggests that DUBA interacts with TRAF3, whose K63-linked polyubiquitination is required for TLR-and RLR-mediated signaling."
32215003
sparser
"Fig. 4 shows the TRAF3-DUBA interaction model that we obtained by PRISM [36], [37], [38], in which the concave crevice on TRAF-C of TRAF3 is in contact with DUBA."
27208423
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
TRAF3 inhibits OTUD5.
| 1
TRAF3 inhibits OTUD5. 1 / 1
| 1
reach
"TRAF3 activation is negatively regulated by Suppressor of Cytokine Signalling 3 (SOCS3) and Deubiquitinating Enzyme A (DUBA) [XREF_BIBR]."
28553556
OTUD5 affects TRIM25
1 | 2 12
OTUD5 binds TRIM25.
1 | 12
TRIM25 binds OTUD5. 10 / 13
1 | 12
sparser
"Our studies reveal a critical role of OTUD5 in tumorigenesis, as indicated through its interaction with TRIM25, suggesting that the OTUD5-TRIM25 axis acts as an important transcriptional regulator in tumor progression."
32826889
sparser
"Taken together, our study sheds light into regulation and function of the OTUD5-TRIM25 axis, suggesting it as a potential target for tumor therapy."
32826889
biogrid
No evidence text available
29117863
sparser
"However, some TRIM25 coprecipitated with the Flag-OTUD5-ΔUIM, indicating that the UIM may not be the sole interaction site and that TRIM25 may bind to the other parts of the OTUD5 protein (Fig.  xref )."
32826889
sparser
"In addition, the OTUD5/TRIM25 double knockdown cells formed smaller tumor sphere than did the OTUD5-depleted cells, demonstrating that the OTUD5-TRIM25 axis plays an important role in the regulation of tumor growth."
32826889
sparser
"To determine the importance of UIM in the interaction between OTUD5 and TRIM25, we transfected Hep3B cells with plasmid constructs expressing Flag-tagged wild-type OTUD5 (Flag-OTUD5-WT) and Flag-tagged OTUD5 with the UIM domain deleted (Flag-OTUD5-ΔUIM) (Fig.  xref )."
32826889
sparser
"A significantly lower level of TRIM25 was obtained with Flag-OTUD5-ΔUIM than with Flag-OTUD5-WT, suggesting that the UIM domain is important for the interaction between OTUD5 and TRIM25."
32826889
sparser
"The enriched biological processes were dominated by cell cycle and cell division processes, implying that the OTUD5-TRIM25 axis may affect cell proliferation by regulating the cell cycle (Fig.  xref )."
32826889
sparser
"We confirmed the interaction between endogenous OTUD5 and TRIM25 by the immunoprecipitation (IP) of Hep3B cells lysates."
32826889
sparser
"We tested whether the OTUD5-TRIM25 axis would affect tumor growth in a mouse model."
32826889
OTUD5 ubiquitinates TRIM25.
| 1
Modified OTUD5 leads to the ubiquitination of TRIM25. 1 / 1
| 1
reach
"Our findings reveal a mechanism whereby OTUD5 regulates gene transcription and suppresses tumorigenesis by deubiquitinating TRIM25, providing a potential target for oncotherapy."
32826889
OTUD5 increases the amount of TRIM25.
| 1
OTUD5 increases the amount of TRIM25. 1 / 1
| 1
reach
"Further investigation reveals that OTUD5 depletion leads to the enhanced transcriptional activity of TRIM25 and the inhibited expression of PML by altering the ubiquitination level of TRIM25."
32826889
UBR5 affects OTUD5
| 7 5
UBR5 binds OTUD5.
| 5 5
UBR5 binds OTUD5. 8 / 8
| 5 3
reach
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
sparser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
reach
"OTUD5 localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis."
30508113
sparser
"First, OTUD5 interacts with UBR5 and represses RNA Pol II-mediated elongation and RNA synthesis."
32268558
reach
"The OTUD5 and UBR5 complex regulates FACT mediated transcription at damaged chromatin."
30508113
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
sparser
"Mass spectrometry coupled to short interfering RNA (siRNA) screening of ubiquitinated proteins in Duba −/− Th17 cells revealed that DUBA directly bound and deubiquitinated UBR5 (Ubiquitin protein ligase E3 component n-recognin 5)."
34635393
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
UBR5 inhibits OTUD5.
| 1
UBR5 bound to OTUD5 inhibits OTUD5. 1 / 1
| 1
reach
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
UBR5 activates OTUD5.
| 1
UBR5 activates OTUD5. 1 / 1
| 1
reach
"UBR5 destabilizes DUBA through ubiquitylation, whereas DUBA stabilizes UBR5 in activated T cells by attenuating degradative auto-ubiquitylation, triggering UBR5 mediated ubiquitylation of the transcription factor RORyt in response to TGF-beta [XREF_BIBR]."
27834739
OTUD5 affects UBR5
1 | 6 5
OTUD5 binds UBR5.
| 5 5
UBR5 binds OTUD5. 8 / 8
| 5 3
reach
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
sparser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
reach
"OTUD5 localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis."
30508113
sparser
"First, OTUD5 interacts with UBR5 and represses RNA Pol II-mediated elongation and RNA synthesis."
32268558
reach
"The OTUD5 and UBR5 complex regulates FACT mediated transcription at damaged chromatin."
30508113
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
sparser
"Mass spectrometry coupled to short interfering RNA (siRNA) screening of ubiquitinated proteins in Duba −/− Th17 cells revealed that DUBA directly bound and deubiquitinated UBR5 (Ubiquitin protein ligase E3 component n-recognin 5)."
34635393
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
OTUD5 deubiquitinates UBR5.
1 | 1
OTUD5 deubiquitinates UBR5. 2 / 2
1 | 1
reach
"When DUBA deubiquitylates UBR5 and rescues it from degradation, UBR5 is free to polyubiquitylate RORgammaT, driving its degradation and consequently limiting Th17 differentiation."
27183634
ubibrowser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells. DUBA accumulated in activated T cells and stabilized UBR5, which then ubiquitylated ROR纬t in response to TGF-尾 signalling.?"
25470037
PDCD5 affects OTUD5
5 | 1 1 3
PDCD5 binds OTUD5.
5 | 3
OTUD5 binds PDCD5. 7 / 7
5 | 2
biogrid
No evidence text available
25499082
sparser
"Moreover, OTUD5 interacts with PDCD5 in response to etoposides, which is a prerequisite for the stabilization and activation of p53 xref , xref ."
32826889
biogrid
No evidence text available
25499082
sparser
"Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98."
25499082
biogrid
No evidence text available
25499082
biogrid
No evidence text available
25499082
biogrid
No evidence text available
25499082
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
PDCD5 activates OTUD5.
| 1 1
PDCD5 activates OTUD5. 2 / 2
| 1 1
eidos
"Therefore , it was concluded that OTUD5 could impede the proliferation , migration , and invasion of HCC827 cells while facilitating their apoptosis , and the role of OTUD5 was partly mediated by PDCD5 ."
| PMC
reach
"Conversely, PDCD5 knockdown greatly attenuated the effect of OTUD5 on p53 activation."
25499082
OTUD5 affects Interferon
| 9
OTUD5 inhibits Interferon.
| 8
OTUD5 inhibits Interferon. 8 / 9
| 8
reach
"DUBA inhibits type I IFN production in the absence of IL-1RI signaling."
21115691
reach
"OTUD5 has been shown to suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein."
24143256
reach
"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I and MDA5-mediated IFN induction."
28717359
reach
"They showed that reducing the expression of DUBA augments the IFN response to poly(I:C) whereas ectopic expression of DUBA blocks the IFN response."
22312431
reach
"It has been demonstrated that the deubiquitinating enzymes A20 and CYLD inhibit NF-kappaB signaling by targeting TRAF6 upstream of IKK, while the deubiquitinating protein DUBA inhibits type I interferon activity by targeting TRAF3."
20434986
reach
"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I/MDA5-mediated IFN induction (52)."
28717359
reach
"The activation of TLR4 and TLR3 stimulates the K 63 -linked ubiquitination of TRAF3, which is required for the activation of IRF3 and the production of type I IFNs, and DUBA removes K 63 -linked ubiquitin chains from TRAF3, thereby inhibiting type I IFN responses."
23674823
reach
"Indeed, DUBA and OTUD5, a DUB which selectively disassembles Lys63 linked ubiquitin chains on TRAF3, has been shown to suppress the production of type I interferon by reducing the level of TRAF3-TBK1 interaction XREF_BIBR."
28327663
OTUD5 deubiquitinates Interferon.
| 1
OTUD5 deubiquitinates Interferon. 1 / 1
| 1
reach
"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
22017431
OTUD5 inhibits innate immune response. 8 / 8
| 8
reach
"It has been reported that OTUD5 could suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein TRAF3."
24143256
reach
"OTUD5 has been shown to suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein."
24143256
reach
"DUBA, a member of the ovarian tumor (OTU) domain containing cysteine protease superfamily, was shown to suppress the type I IFN dependent innate immune response by cleaving the K63 polyubiquitin chain on TRAF3."
21115691
reach
"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63 based chains XREF_BIBR, XREF_BIBR, and USP15 inhibits the NFkappaB pathway by removing K48-Ub from IkappaBalpha, preventing its degradation XREF_BIBR."
24854014
reach
"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63-based chains [55], [56], and USP15 inhibits the NFκB pathway by removing K48-Ub from IκBα, preventing its degradation [57]."
24854014
reach
"Also known as DUBA (deubiquitinating enzyme A), the OTUD5 protein was shown to suppress type-I interferon (IFN-I) dependent innate immune response, by cleaving the poly-ubiquitin chain from the IFN-I adaptor protein, thus causing the disassociation of the adaptor from the downstream signaling complex, and ultimately the interruption of the IFN-I signaling cascade."
33675743
reach
"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63-based chains [55, 56] , and USP15 inhibits the NFkB pathway by removing K48-Ub from IkBa, preventing its degradation [57] ."
24854014
reach
"Cellular proteins DUBA and CYLD also negatively regulate the innate immune response."
22312431
OTUD5 affects STING1
| 1 5 1
OTUD5 inhibits STING1.
| 1 2
OTUD5 inhibits STING1. 3 / 3
| 1 2
eidos
"On the other hand , OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation , thus maintain the stability of STING and promote activation of STING pathway ( 87 ) ( 88 ) ( 89 ) ."
35603197
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87–89)."
35603197
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87) (88) (89) ."
35603197
OTUD5 activates STING1.
| 3
OTUD5 activates STING1. 3 / 3
| 3
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87–89)."
35603197
reach
"Similarly, OTUD5 promotes the protein stability of STING via cleaving the K48-linked polyubiquitin chains."
34707613
reach
"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87) (88) (89) ."
35603197
OTUD5 binds STING1.
| 1
OTUD5 binds STING1. 1 / 1
| 1
sparser
"Here, we report that the deubiquitinase OTUD5 interacts with STING, cleaves its K48-linked polyubiquitin chains, and promotes its stability."
32879469
OTUD5 affects cell growth
| 4 1
OTUD5 inhibits cell growth. 5 / 5
| 4 1
eidos
"OTUD5 knockdown promoted cell growth in a TRIM25-dependent manner ."
32826889
eidos
"In the current study , we find that OTUD5 knockdown accelerates cell growth in a TRIM25-dependent manner ."
32826889
eidos
"OTUD5 knockdown accelerated cell growth ."
32826889
reach
"Through an unbiased RNAi screen, knockdown of OTUD5 is shown to significantly accelerate cell growth."
32826889
eidos
"Through an unbiased RNAi screen , knockdown of OTUD5 is shown to significantly accelerate cell growth ."
32826889
Ubiquitin affects OTUD5
| 1 3
Ubiquitin binds OTUD5.
| 3
sparser
"In the crystal structure of the Ser177-phosphorylated form of OTUD5 bound with ubiquitin ( xref ), the phosphate group has intramolecular interactions with other OTUD5 polar residues (including Arg272), and also has intermolecular interactions with the C-terminal tail of the bound ubiquitin, precisely orienting its C-terminus for catalysis."
33748114
sparser
"The crystal structure of the Ub-aldehyde complex with phosphorylated OTUD5 reveals a remarkable interaction between the phosphorylated Ser177 of OTUD5 and the guanidinium moiety of Arg74 of the bound ubiquitin showing that the phosphorylation is essential for the DUB activity [ xref ]."
32512887
sparser
"In the crystal structure of OTUD5 bound with ubiquitin ( xref ), Asp256, Arg274, and Asn293 are located on the surface of the protein, and form no direct interactions with ubiquitin ( xref )."
33748114
Ubiquitin activates OTUD5.
| 1
Ubiquitin activates OTUD5. 1 / 1
| 1
reach
"An intricate web of interactions involving the phosphate and the C-terminal tail of ubiquitin cause DUBA to fold around its substrate, revealing why phosphorylation is essential for deubiquitinase activity."
22245969
UBC affects OTUD5
4 |
UBC binds OTUD5. 4 / 4
4 |
biogrid
No evidence text available
22245969
biogrid
No evidence text available
23827681
biogrid
No evidence text available
17991829
biogrid
No evidence text available
28190767
OTUD5 affects polyubiquitin chains
| 4
OTUD5 binds polyubiquitin chains.
| 3
OTUD5 binds polyubiquitin chains. 1 / 1
| 1
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
OTUD5 binds K48 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
OTUD5 activates polyubiquitin chains.
| 1
OTUD5 activates polyubiquitin chains. 1 / 1
| 1
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
OTUD5 affects apoptotic process
| 2 2
OTUD5 activates apoptotic process.
| 2 1
OTUD5 activates apoptotic process. 3 / 3
| 2 1
reach
"The function of OTUD5 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent apoptosis in response to DNA damage stress."
24143256
eidos
"Knockdown of OTUD5 accelerated the proliferation , migration , and invasion of A549 cells , and inhibited their apoptosis Next , A549 cells were used for the following experiment ."
| PMC
eidos
"It was proved that OTUD5 inhibited the proliferation and metastasis of NSCLC cells but promoted their apoptosis via regulating p53 and PDCD5 ."
| PMC
OTUD5 inhibits apoptotic process.
| 1
reach
"Knockdown of OTUD5 clearly impeded the apoptosis, consistent with a weaker activation of p53 (XREF_FIG)."
24143256
OTUD5 affects Ubiquitin
| 1 3
OTUD5 binds Ubiquitin.
| 3
sparser
"In the crystal structure of the Ser177-phosphorylated form of OTUD5 bound with ubiquitin ( xref ), the phosphate group has intramolecular interactions with other OTUD5 polar residues (including Arg272), and also has intermolecular interactions with the C-terminal tail of the bound ubiquitin, precisely orienting its C-terminus for catalysis."
33748114
sparser
"The crystal structure of the Ub-aldehyde complex with phosphorylated OTUD5 reveals a remarkable interaction between the phosphorylated Ser177 of OTUD5 and the guanidinium moiety of Arg74 of the bound ubiquitin showing that the phosphorylation is essential for the DUB activity [ xref ]."
32512887
sparser
"In the crystal structure of OTUD5 bound with ubiquitin ( xref ), Asp256, Arg274, and Asn293 are located on the surface of the protein, and form no direct interactions with ubiquitin ( xref )."
33748114
OTUD5 activates Ubiquitin.
| 1
OTUD5 activates Ubiquitin. 1 / 1
| 1
reach
"An intricate web of interactions involving the phosphate and the C-terminal tail of ubiquitin cause DUBA to fold around its substrate, revealing why phosphorylation is essential for deubiquitinase activity."
22245969
OTUD5 affects UBC
4 |
UBC binds OTUD5. 4 / 4
4 |
biogrid
No evidence text available
22245969
biogrid
No evidence text available
23827681
biogrid
No evidence text available
17991829
biogrid
No evidence text available
28190767
OTUD5 affects IRF3
| 3 1
OTUD5 inhibits IRF3.
| 2 1
OTUD5 inhibits IRF3. 3 / 3
| 2 1
sparser
"These results suggest that DUBA inhibits IRF3 by functioning as a K63-specific DUB that antagonizes the function of TRAF3."
19281271
reach
"Removal of Lys 63 -linked polyubiquitin chains from RIG-I and TRAF3 by cylindromatosis (CYLD) and deubiquitinating enzyme A (DUBA), respectively, inhibits the RIG-I-dependent activation of IRF3."
24399297
reach
"These results suggest that DUBA inhibits IRF3 by functioning as a K63 specific DUB that antagonizes the function of TRAF3."
19281271
OTUD5 activates IRF3.
| 1
OTUD5 activates IRF3. 1 / 1
| 1
reach
"RNAi of DUBA enhances IRF3 activation, whereas overexpression of DUBA has the opposite effect."
19281271
OTUD5 affects IL17A
| 1 3
OTUD5 inhibits IL17A.
| 1 1
OTUD5 inhibits IL17A. 2 / 2
| 1 1
eidos
"OTUD5 inhibits the production of IL-17A by blocking the UBR5-mediated proteasomal degradation of RORgammat17 ."
32826889
reach
"T-cell specific loss of DUBA therefore results in reduced levels of UBR5, stabilization of RORgammaT, and increased IL-17A production in response to TCR stimulation 76."
27183634
OTUD5 decreases the amount of IL17A.
| 1
OTUD5 decreases the amount of IL17A. 1 / 1
| 1
reach
"Accumulation of the deubiquitinating enzyme DUBA (OTUD5) negatively regulates RORgammat stability and IL-17 expression in T cells by stabilizing the ubiquitin ligase UBR5, which ubiquitinates RORgammat in response to TGF-beta, leading to RORgammat degradation and decreased IL-17 expression."
31386594
OTUD5 activates IL17A.
| 1
OTUD5 activates IL17A. 1 / 1
| 1
reach
"On the other hand, DUBA deficient Tregs, which still have immunosuppressive functions in vitro and in vivo, can produce IL-17A under TCR stimulation."
32850399
OTUD5 affects IFN-I
| 4
OTUD5 inhibits IFN-I.
| 2
OTUD5 inhibits IFN-I. 2 / 2
| 2
reach
"The knockout of OTUD5 leads to faster turnover of STING and impairs IFN-I signaling following cytosolic DNA stimulation, whereas Lyz2-Cre Otud5fl/Y mice and CD11-Cre Otud5fl/Y mice show higher susceptibility to HSV-1 infection than their corresponding control littermates (69)."
34707613
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
OTUD5 activates IFN-I.
| 2
OTUD5 activates IFN-I. 2 / 2
| 2
reach
"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
34707613
reach
"Among the DUBs that interact with STING, five members, namely CYLD, OTUD5, USP18 (also termed UBP43), USP20, and USP44, have been demonstrated to promote IFN-I production and antiviral responses."
34707613
OTUD5 affects DDX58
| 4
OTUD5 inhibits DDX58.
| 3
OTUD5 inhibits DDX58. 3 / 3
| 3
reach
"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I/MDA5-mediated IFN induction (52)."
28717359
reach
"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I and MDA5-mediated IFN induction."
28717359
reach
"In addition, A20, NLRX1, PIN1, DUBA and Triad3A deregulate RIG-I mediated signaling by inhibiting MAVS, IRF3 and TRAF3."
21292167
OTUD5 deubiquitinates DDX58.
| 1
OTUD5 leads to the deubiquitination of DDX58. 1 / 1
| 1
reach
"Other DUBs that target the RIG-I and MDA5 pathway include CYLD and DUBA which target RIG-I and TRAF3 ubiquitination respectively (XREF_FIG)."
22435550
Polyubiquitin chains affects OTUD5
| 3
OTUD5 binds polyubiquitin chains. 1 / 1
| 1
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
OTUD5 binds K48 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
Lipopolysaccharide affects OTUD5
| 1 2
Lipopolysaccharide activates OTUD5. 3 / 3
| 1 2
reach
"As DUBA protein is also increased in macrophages by LPS stimulation, it may also function as part of a negative feedback circuit."
18703349
eidos
"As OTUD5 is induced by LPS stimulation , it might act as a negative feedback regulator of IFN signaling by targeting TRAF3 [ 119 ] ."
33808506
reach
"As DUBA protein is also increased in macrophages by LPS stimulation, it may also function as part of a negative feedback circuit.Another OTU DUB family protein, the tumor suppressor, CYLD, has been identified as a negative regulator of RIG-I by two groups [61, 62] ."
18703349
Doxorubicin affects OTUD5
1 | 2
Doxorubicin inhibits OTUD5.
| 1
Doxorubicin inhibits OTUD5. 1 / 1
| 1
reach
"As shown in XREF_FIG after Doxorubicin treatment depletion of OTUD5 clearly prevented the efficient deubiquitination of p53 that is associated with protein accumulation (XREF_FIG)."
24143256
Doxorubicin decreases the amount of OTUD5.
1 |
Doxorubicin decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
29803840
Doxorubicin activates OTUD5.
| 1
Doxorubicin activates OTUD5. 1 / 1
| 1
reach
"U2OS cells transfected with scramble shRNA or OTUD5 shRNA were treated with Doxorubicin."
24143256
OTUD5 activates cell differentiation.
| 2
OTUD5 activates cell differentiation. 2 / 2
| 2
reach
"Thus, OTUD5 controls neural cell fate commitment by regulating chromatin accessibility at neural- and neural crest specific enhancers to enable activation of transcriptional networks that drive the differentiation program."
| PMC
reach
"Intriguingly, this separation-of-function mutant (OTUD5 DeltaCterm) failed to support neural crest differentiation and showed aberrant CNS precursor formation (XREF_FIG and fig."
| PMC
OTUD5 inhibits cell differentiation.
| 1
reach
"Indeed, knockout of Otud5 is embryonic lethal in mice and OTUD5 depleted hESCs are defective in neuroectodermal differentiation, which can be rescued by re-expression of wild-type OTUD5 [XREF_BIBR]."
33335288
OTUD5 affects XRCC5
| 2 1
OTUD5 binds XRCC5.
| 1 1
XRCC5 binds OTUD5. 2 / 2
| 1 1
sparser
"OTUD5 interacts with Ku80 to positively regulate non-homologous end joining NHEJ-mediated repair ( xref )."
32655987
reach
"OTUD5 interacts with Ku80 to positively regulate non homologous end joining NHEJ mediated repair."
32655987
OTUD5 inhibits XRCC5.
| 1
OTUD5 inhibits XRCC5. 1 / 1
| 1
reach
"OTUD5 also stabilises Ku80, loss of OTUD5 reduces NHEJ repair efficiency [11] (Figure 2)."
31769469
OTUD5 affects TRAF6
1 | 2
OTUD5 inhibits TRAF6.
| 1
OTUD5 inhibits TRAF6. 1 / 1
| 1
reach
"Structural data suggest that 1) Toll and IL-1R (TIR) domain containing regulators (BCAP, SIGIRR, and ST2) interfere with TIR domain signalosome formation; 2) major deubiquitinases such as A20, CYLD, and DUBA prevent association of TRAF6 and TRAF3 with their partners, inaddition to removing K63 linked ubiquitin chains that serve as a docking platform for downstream effectors; 3) alternative downstream pathways of TLRs also restrict signaling by competing to bind common partners through shared binding sites."
26276688
OTUD5 deubiquitinates TRAF6.
1 |
OTUD5 deubiquitinates TRAF6. 1 / 1
1 |
ubibrowser
"Given that TRAF3 may be dispensable for RIG-I signalling?92, it cannot be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
24375678
OTUD5 activates TRAF6.
| 1
OTUD5 activates TRAF6. 1 / 1
| 1
reach
"Moreover, the adaptor proteins TRAF3 and TRAF6 are targeted by the cellular proteins DUBA and A20 XREF_BIBR, XREF_BIBR, and TBK1 is sequestered by SIKE XREF_BIBR."
21677781
OTUD5 affects TNF
| 3
OTUD5 binds TNF.
| 2
TNF binds OTUD5. 2 / 2
| 2
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
reach
"DUBA bound tumor necrosis factor receptor associated factor 3 (TRAF3), an adaptor protein essential for the IFN-I response."
17991829
OTUD5 activates TNF.
| 1
OTUD5 activates TNF. 1 / 1
| 1
reach
"OTUD5 expression was enhanced by IFN-gamma through a p38 and MAPK dependent mechanism and the AS induced knockdown of OTUD5 in LPMCs of IBD patients and colitic mice reduced TNF-alpha."
34232309
OTUD5 affects HDAC2
| 2 1
OTUD5 binds HDAC2. 2 / 2
| 2
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
reach
"S5), we show that OTUD5 interacts with and targets ARID1A/B and HDAC2, proteins that are mutated in Coffin-Siris and Cornelia de Lange syndromes, respectively."
| PMC
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
IFNG affects OTUD5
| 1 2
IFNG activates OTUD5.
| 1 1
IFNG activates OTUD5. 2 / 2
| 1 1
eidos
"OTUD5 expression was enhanced by IFN-gamma through a p38 / MAPK-dependent mechanism and the AS-induced knockdown of OTUD5 in LPMCs of IBD patients and colitic mice reduced TNF-alpha ."
34232309
reach
"Recently, OTUD5 was found to be up-regulated in the intestinal inflammatory tissues of IBD patients and TNBS-induced colitis mice, and IFN-γ was found to up-regulate OTUD5’s expression through a p38/MAPK-dependent mechanism."
34956195
IFNG increases the amount of OTUD5.
| 1
IFNG increases the amount of OTUD5. 1 / 1
| 1
reach
"OTUD5 expression was enhanced by IFN-gamma through a p38 and MAPK dependent mechanism and the AS induced knockdown of OTUD5 in LPMCs of IBD patients and colitic mice reduced TNF-alpha."
34232309
HDAC2 affects OTUD5
| 2 1
OTUD5 binds HDAC2. 2 / 2
| 2
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
reach
"S5), we show that OTUD5 interacts with and targets ARID1A/B and HDAC2, proteins that are mutated in Coffin-Siris and Cornelia de Lange syndromes, respectively."
| PMC
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
Vasotocin affects OTUD5
| 1 1
Vasotocin inhibits OTUD5. 2 / 2
| 1 1
reach
"XREF_FIG d, AVT also decreases Otud4, Otud5 and Otud7b in addition to Otub1 and c-Maf."
33627137
eidos
"As shown in Fig. 5d , AVT also decreases Otud4 , Otud5 and Otud7b in addition to Otub1 / c-Maf ."
33627137
Pirinixic acid affects OTUD5
2 |
Pirinixic acid decreases the amount of OTUD5.
1 |
Pirinixic acid decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates OTUD5.
1 |
Pirinixic acid activates OTUD5. 1 / 1
1 |
ctd
No evidence text available
19710929
MiR-210 affects OTUD5
| 2
MiR-210 increases the amount of OTUD5.
| 1
MiR-210 increases the amount of OTUD5. 1 / 1
| 1
reach
"The expression patterns between miR-210 and DUBA showed a negative correlation, which indicated that miR-210 can target and downregulate the expression of DUBA."
29408541
MiR-210 decreases the amount of OTUD5.
| 1
MiR-210 decreases the amount of OTUD5. 1 / 1
| 1
reach
"By means of the dual luciferase reporter assay, a direct interaction between miR-210 and the 3 untranslated region (UTR) of Deubiquitinating enzyme A (DUBA) was confirmed, and we found that miR-210 could reduce the luciferase levels of wild-type DUBA 3 ' UTR, whereas mutant-type led to a complete abrogation of the negative effect."
29408541
Folic acid affects OTUD5
2 |
Folic acid demethylates OTUD5.
1 |
Folic acid demethylates OTUD5. 1 / 1
1 |
ctd
No evidence text available
20938992
Folic acid decreases the amount of OTUD5.
1 |
Folic acid decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
20938992
Choline affects OTUD5
2 |
Choline demethylates OTUD5.
1 |
Choline demethylates OTUD5. 1 / 1
1 |
ctd
No evidence text available
20938992
Choline decreases the amount of OTUD5.
1 |
Choline decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
20938992
XRCC5 affects OTUD5
| 1 1
XRCC5 binds OTUD5. 2 / 2
| 1 1
sparser
"OTUD5 interacts with Ku80 to positively regulate non-homologous end joining NHEJ-mediated repair ( xref )."
32655987
reach
"OTUD5 interacts with Ku80 to positively regulate non homologous end joining NHEJ mediated repair."
32655987
UBD affects OTUD5
| 1 1
UBD binds OTUD5. 2 / 2
| 1 1
sparser
"So far, no crystal structures of diubiquitin bound to DUBA are available and therefore the structural basis for ubiquitin chain linkage specificity is not known."
30232733
reach
"So far, no crystal structures of diubiquitin bound to DUBA are available and therefore the structural basis for ubiquitin chain linkage specificity is not known."
30232733
TNF affects OTUD5
| 2
TNF binds OTUD5. 2 / 2
| 2
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
reach
"DUBA bound tumor necrosis factor receptor associated factor 3 (TRAF3), an adaptor protein essential for the IFN-I response."
17991829
SUPT16H affects OTUD5
| 2
SUPT16H binds OTUD5. 1 / 1
| 1
sparser
"In addition, OTUD5 interacts with the FACT component SPT16 and antagonizes histone H2A deposition at DSBs [ xref ]."
32268558
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
SMARCA4 affects OTUD5
| 1 1
SMARCA4 binds OTUD5. 2 / 2
| 1 1
reach
"Further supporting the idea that OTUD5 regulates cell fate commitment through stabilizing chromatin remodelers, we observed that OTUD5 regulated neural enhancers were often bound by SMARCA4, a component of the BAF complex recruited by ARID1A/B in neural progenitor cells (XREF_FIG)."
| PMC
sparser
"Further supporting the idea that OTUD5 regulates cell fate commitment through stabilizing chromatin remodelers, we observed that OTUD5-regulated neural enhancers were often bound by SMARCA4 ( xref ), a component of the BAF complex recruited by ARID1A/B ( xref ) in neural progenitor cells ( xref )."
| PMC
OTUD5 affects transformation malignant A549 cells
| 2
OTUD5 inhibits transformation malignant A549 cells. 2 / 2
| 2
eidos
"This study demonstrated that OTUD5 could inhibit the transformation of malignant phenotypes of A549 cells by inducing the expression of p53 , suggesting that OTUD5 may be used as a potential therapeutic target for NSCLC treatment ."
| PMC
eidos
"Therefore , it was concluded that OTUD5 impeded the transformation of malignant phenotypes of A549 cells via positively regulating p53 expression ."
| PMC
OTUD5 affects polyubiquitin chain
| 2
OTUD5 inhibits polyubiquitin chain. 2 / 2
| 2
reach
"DUBA, a member of the ovarian tumor (OTU) domain containing cysteine protease superfamily, was shown to suppress the type I IFN dependent innate immune response by cleaving the K63 polyubiquitin chain on TRAF3."
21115691
reach
"It has been reported that OTUD5 could suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein TRAF3."
24143256
OTUD5 affects migration invasion HCC827 cells
| 2
OTUD5 inhibits migration invasion HCC827 cells. 2 / 2
| 2
eidos
"Therefore , it was concluded that OTUD5 could impede the proliferation , migration , and invasion of HCC827 cells while facilitating their apoptosis , and the role of OTUD5 was partly mediated by PDCD5 ."
| PMC
eidos
"Knockdown of OTUD5 promoted the proliferation , migration , and invasion of HCC827 cells while inhibiting their apoptosis via regulating PDCD5 ."
| PMC
OTUD5 affects migration invasion A549 cells
| 2
OTUD5 inhibits migration invasion A549 cells. 2 / 2
| 2
eidos
"Knockdown of OTUD5 accelerated the proliferation , migration , and invasion of A549 cells , and inhibited their apoptosis Next , A549 cells were used for the following experiment ."
| PMC
eidos
"Knockdown of OTUD5 accelerated the proliferation , migration , and invasion of A549 cells while inhibiting their apoptosis ."
| PMC
OTUD5 inhibits cell population proliferation. 2 / 2
| 1 1
reach
"On the other hand, over-expression of OTUD5 suppressed NSCLC cell proliferation, invasion, and migration."
35765958
eidos
"Two different lung tumor cell lines , H1299 and A549 , were used to investigate whether siRNA-mediated depletion of OTUD5 also promoted cell proliferation ."
32826889
OTUD5 affects UBD
| 1 1
UBD binds OTUD5. 2 / 2
| 1 1
sparser
"So far, no crystal structures of diubiquitin bound to DUBA are available and therefore the structural basis for ubiquitin chain linkage specificity is not known."
30232733
reach
"So far, no crystal structures of diubiquitin bound to DUBA are available and therefore the structural basis for ubiquitin chain linkage specificity is not known."
30232733
OTUD5 affects TLR3
| 2
OTUD5 inhibits TLR3. 2 / 2
| 2
reach
"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I and MDA5-mediated IFN induction."
28717359
reach
"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I/MDA5-mediated IFN induction (52)."
28717359
OTUD5 affects SUPT16H
| 2
SUPT16H binds OTUD5. 1 / 1
| 1
sparser
"In addition, OTUD5 interacts with the FACT component SPT16 and antagonizes histone H2A deposition at DSBs [ xref ]."
32268558
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
OTUD5 affects SMARCA4
| 1 1
SMARCA4 binds OTUD5. 2 / 2
| 1 1
reach
"Further supporting the idea that OTUD5 regulates cell fate commitment through stabilizing chromatin remodelers, we observed that OTUD5 regulated neural enhancers were often bound by SMARCA4, a component of the BAF complex recruited by ARID1A/B in neural progenitor cells (XREF_FIG)."
| PMC
sparser
"Further supporting the idea that OTUD5 regulates cell fate commitment through stabilizing chromatin remodelers, we observed that OTUD5-regulated neural enhancers were often bound by SMARCA4 ( xref ), a component of the BAF complex recruited by ARID1A/B ( xref ) in neural progenitor cells ( xref )."
| PMC
OTUD5 affects PML
| 1 1
OTUD5 decreases the amount of PML.
| 1
OTUD5 decreases the amount of PML. 1 / 1
| 1
reach
"Further investigation reveals that OTUD5 depletion leads to the enhanced transcriptional activity of TRIM25 and the inhibited expression of PML by altering the ubiquitination level of TRIM25."
32826889
OTUD5 binds PML.
| 1
OTUD5 binds PML. 1 / 1
| 1
sparser
"Knocking down OTUD5 significantly inhibited the formation of PML-NBs, a finding that was consistent with the involvement of OTUD5 in the regulation of PML expression (Fig.  xref )."
32826889
OTUD5 affects Neoplasms
| 2
OTUD5 inhibits Neoplasms.
| 1
OTUD5 inhibits Neoplasms. 1 / 1
| 1
eidos
"Briefly , OTUD5 potentially inhibits tumor progression by regulating PML transcription by deubiquitinating TRIM25 ( Fig. 8g ) ."
32826889
OTUD5 activates Neoplasms.
| 1
OTUD5 activates Neoplasms. 1 / 1
| 1
eidos
"Here , we report that the deubiquitinating enzyme , ovarian tumor domain-containing protein 5 ( OTUD5 ) , can activate the mTOR signaling pathway , promote cancer progression , and show its oncogenic potential in bladder cancer ."
36085200
OTUD5 affects NSCLC cells
| 2
OTUD5 inhibits NSCLC cells. 2 / 2
| 2
eidos
"OTUD5 impeded the progression of NSCLC cells via regulating p53 ."
| PMC
eidos
"* p < .05 , * * p < .01 , and * * * p < .001 [ Colour figure can be viewed at wileyonlinelibrary.com ] OTUD5 impeded the progression of NSCLC cells via regulating p53 In order to study whether OTUD5 regulates p53 expression in NSCLC , OTUD5 siRNA and NC siRNA were transfected into A549 cells , respectively ."
| PMC
OTUD5 affects K63
| 2
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
OTUD5 affects HCFC1
| 1 1
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
OTUD5 binds HCFC1. 1 / 1
| 1
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
OTUD5 affects GRN
2 |
OTUD5 binds GRN. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
OTUD5 affects E3_Ub_ligase
| 1 1
OTUD5 binds E3_Ub_ligase.
| 1
sparser
"In order to test whether OTUD5 associates with an E3 ubiquitin ligase to regulate cell proliferation, the stable Flag-OTUD5/Hep3B cell line was established by transfecting Hep3B cells with plasmids expressing pCIN4-Flag-OTUD5 xref ."
32826889
OTUD5 activates E3_Ub_ligase.
| 1
OTUD5 activates E3_Ub_ligase. 1 / 1
| 1
reach
"Given that TRAF3 may be dispensable for RIG-I signalling XREF_BIBR, it can not be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
24375678
OTUD5 affects Dnmt1
| 2
OTUD5 binds Dnmt1. 2 / 2
| 2
sparser
"The OTUD5 UIM domain can bind both Lys 48 - and Lys 63 -linked polyubiquitin chains xref , xref ."
32826889
sparser
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
OTUD5 affects ARID1A/B
| 2
OTUD5 binds ARID1A/B. 2 / 2
| 2
reach
"S5), we show that OTUD5 interacts with and targets ARID1A/B and HDAC2, proteins that are mutated in Coffin-Siris and Cornelia de Lange syndromes, respectively."
| PMC
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
L-methionine affects OTUD5
2 |
L-methionine demethylates OTUD5.
1 |
L-methionine demethylates OTUD5. 1 / 1
1 |
ctd
No evidence text available
20938992
L-methionine decreases the amount of OTUD5.
1 |
L-methionine decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
20938992
K63 affects OTUD5
| 2
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
IL-1RI affects OTUD5
| 2
IL-1RI decreases the amount of OTUD5. 2 / 2
| 2
reach
"Consistent with the protein data, Duba mRNA levels were increased in freshly isolated splenocytes and mesenteric LN derived cells from Il1r1 -/- mice (XREF_FIG), suggesting that IL-1RI signaling negatively regulates DUBA transcription."
21115691
reach
"We show that IL-1RI signaling down-regulates the expression of deubiquitinating enzyme A (DUBA) and consequently enhances the Lys63 linked ubiquitination of TNF receptor associated factor 3 (TRAF3), which is necessary for the transcription of antiinflammatory cytokines."
21115691
HCFC1 affects OTUD5
| 1 1
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
OTUD5 binds HCFC1. 1 / 1
| 1
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
GRN affects OTUD5
2 |
OTUD5 binds GRN. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
Dnmt1 affects OTUD5
| 2
OTUD5 binds Dnmt1. 2 / 2
| 2
sparser
"The OTUD5 UIM domain can bind both Lys 48 - and Lys 63 -linked polyubiquitin chains xref , xref ."
32826889
sparser
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
ARID1A/B affects OTUD5
| 2
OTUD5 binds ARID1A/B. 2 / 2
| 2
reach
"S5), we show that OTUD5 interacts with and targets ARID1A/B and HDAC2, proteins that are mutated in Coffin-Siris and Cornelia de Lange syndromes, respectively."
| PMC
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
Zinc atom affects OTUD5
1 |
Zinc atom increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
22171008
Urethane affects OTUD5
1 |
Urethane increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
28818685
Tumor necrosis factor receptor-associate affects OTUD5
| 1
OTUD5 binds tumor necrosis factor receptor-associate. 1 / 1
| 1
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
Tumor necrosis factor receptor affects OTUD5
| 1
OTUD5 binds tumor necrosis factor receptor. 1 / 1
| 1
reach
"DUBA bound tumor necrosis factor receptor associated factor 3 (TRAF3), an adaptor protein essential for the IFN-I response."
17991829
Polyubiquitin chains affects K63
| 1
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
Polyubiquitin chains affects K48
| 1
OTUD5 binds K48 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
P53-PDCD5 affects OTUD5
| 1
OTUD5 binds p53-PDCD5. 1 / 1
| 1
reach
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination."
32655987
P.Arg274Trp affects OTUD5
| 1
P.Arg274Trp activates OTUD5. 1 / 1
| 1
reach
"Second, p.Arg274Trp, present in a conserved putative nuclear localization sequence, caused a partial mis localization of OTUD5 to the cytoplasm at steady-state expression in human embryonic stem cells (hESCs)."
| PMC
Methotrexate affects OTUD5
1 |
Methotrexate decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
24449571
Lead diacetate affects OTUD5
1 |
Lead diacetate increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
22609695
Ketone body affects OTUD5
1 |
Ketone body increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
16807920
Hsa-mir-937 affects OTUD5
| 1
Hsa-mir-937 decreases the amount of OTUD5. 1 / 1
| 1
reach
"Moreover, hsa-mir-137, hsa-mir-1913, hsa-mir-937, hsa-mir-607, hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5."
32655987
Hsa-mir-607 affects OTUD5
| 1
Hsa-mir-607 decreases the amount of OTUD5. 1 / 1
| 1
reach
"Moreover, hsa-mir-137, hsa-mir-1913, hsa-mir-937, hsa-mir-607, hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5."
32655987
Hsa-mir-3149 affects OTUD5
| 1
Hsa-mir-3149 decreases the amount of OTUD5. 1 / 1
| 1
reach
"Moreover, hsa-mir-137, hsa-mir-1913, hsa-mir-937, hsa-mir-607, hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5."
32655987
Hsa-mir-1913 affects OTUD5
| 1
Hsa-mir-1913 decreases the amount of OTUD5. 1 / 1
| 1
reach
"Moreover, hsa-mir-137, hsa-mir-1913, hsa-mir-937, hsa-mir-607, hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5."
32655987
Hsa-mir-144 affects OTUD5
| 1
Hsa-mir-144 decreases the amount of OTUD5. 1 / 1
| 1
reach
"Moreover, hsa-mir-137, hsa-mir-1913, hsa-mir-937, hsa-mir-607, hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5."
32655987
Hsa-mir-137 affects OTUD5
| 1
Hsa-mir-137 decreases the amount of OTUD5. 1 / 1
| 1
reach
"Moreover, hsa-mir-137, hsa-mir-1913, hsa-mir-937, hsa-mir-607, hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5."
32655987
Hsa-miR-885-3p affects OTUD5
1 |
Hsa-miR-885-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6873-5p affects OTUD5
1 |
Hsa-miR-6873-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6858-3p affects OTUD5
1 |
Hsa-miR-6858-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6836-5p affects OTUD5
1 |
Hsa-miR-6836-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6782-5p affects OTUD5
1 |
Hsa-miR-6782-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6766-5p affects OTUD5
1 |
Hsa-miR-6766-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6756-5p affects OTUD5
1 |
Hsa-miR-6756-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-6722-3p affects OTUD5
1 |
Hsa-miR-6722-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-664b-5p affects OTUD5
1 |
Hsa-miR-664b-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-654-5p affects OTUD5
1 |
Hsa-miR-654-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-650 affects OTUD5
1 |
Hsa-miR-650 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-6132 affects OTUD5
1 |
Hsa-miR-6132 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-608 affects OTUD5
1 |
Hsa-miR-608 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-575 affects OTUD5
1 |
Hsa-miR-575 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-541-3p affects OTUD5
1 |
Hsa-miR-541-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-520a-5p affects OTUD5
1 |
Hsa-miR-520a-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-505-3p affects OTUD5
1 |
Hsa-miR-505-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-4712-3p affects OTUD5
1 |
Hsa-miR-4712-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4693-3p affects OTUD5
1 |
Hsa-miR-4693-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4676-5p affects OTUD5
1 |
Hsa-miR-4676-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4651 affects OTUD5
1 |
Hsa-miR-4651 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-4443 affects OTUD5
1 |
Hsa-miR-4443 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-4417 affects OTUD5
1 |
Hsa-miR-4417 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-3612 affects OTUD5
1 |
Hsa-miR-3612 decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-339-5p affects OTUD5
1 |
Hsa-miR-339-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-328-3p affects OTUD5
1 |
Hsa-miR-328-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-3120-3p affects OTUD5
1 |
Hsa-miR-3120-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-1909-3p affects OTUD5
1 |
Hsa-miR-1909-3p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23313552
Hsa-miR-1273d affects OTUD5
1 |
Hsa-miR-1273d decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19536157
Hsa-miR-1260b affects OTUD5
1 |
Hsa-miR-1260b decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-let-7e-5p affects OTUD5
1 |
Hsa-let-7e-5p decreases the amount of OTUD5. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Dioxygen affects OTUD5
1 |
Dioxygen increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
22629407
Clofibrate affects OTUD5
1 |
Clofibrate decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
23811191
Caspase death affects OTUD5
| 1
OTUD5 binds caspase death. 1 / 1
| 1
reach
"DUBA physically interacts with the initiator caspase death regulator Nedd2 like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye."
27518434
Bisphenol A affects OTUD5
1 |
Bisphenol A increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
25181051
Benzo[a]pyrene affects OTUD5
1 |
Benzo[a]pyrene increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
22228805
All-trans-retinoic acid increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
23724009
Aflatoxin B1 affects OTUD5
1 |
Aflatoxin B1 demethylates OTUD5. 1 / 1
1 |
ctd
No evidence text available
27153756
Abrine affects OTUD5
1 |
Abrine increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
31054353
Vehicle Emissions affects OTUD5
1 |
ctd
No evidence text available
25560391
VARS1 affects OTUD5
1 |
VARS1 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP11 affects OTUD5
1 |
USP11 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
UBR5 affects SUPT16H
| 1
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
UBR5 affects HDAC2
| 1
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
TRIM35 affects OTUD5
1 |
TRIM35 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
28514442
TRAF3 affects K63
| 1
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
TRAF-C affects RING domain
| 1
OTUD5 binds RING domain and TRAF-C. 1 / 1
| 1
reach
"If DUBA binds to both TRAF-C and the catalytic RING domain of TRAF3, it impedes TRAF3 signaling not only by removing the Ub chains, but also by preventing its interactions.OTUB1 is also a debubiqutinase that targets TRAF3 after viral infection and attenuates virus-triggered IFN production [57]."
27208423
TP53 affects PDCD5
| 1
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
TP53 affects GST
| 1
GST binds TP53 and OTUD5. 1 / 1
| 1
sparser
"As shown in xref , GST-p53 but not GST interacted with the full-length OTUD5."
24143256
TNFAIP3 affects OTUD5
1 |
TNFAIP3 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
28514442
TGFB affects OTUD5
| 1
TGFB activates OTUD5. 1 / 1
| 1
eidos
"In immunomodulation , TGF-beta stimulation leads to excessive OTUD5 production ."
32655987
TALOS-N affects OTUD5
| 1
TALOS-N phosphorylates OTUD5. 1 / 1
| 1
reach
"XREF_FIG shows the predicted secondary structure of non phosphorylated DUBA by TALOS-N."
30232733
reach
"TRAF3 activation is negatively regulated by Suppressor of Cytokine Signalling 3 (SOCS3) and Deubiquitinating Enzyme A (DUBA) [XREF_BIBR]."
28553556
SUPT16H affects UBR5
| 1
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
STING1 affects OTUD5
| 1
OTUD5 binds STING1. 1 / 1
| 1
sparser
"Here, we report that the deubiquitinase OTUD5 interacts with STING, cleaves its K48-linked polyubiquitin chains, and promotes its stability."
32879469
SPT16 affects OTUD5
| 1
OTUD5 binds SPT16. 1 / 1
| 1
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
SP1 affects OTUD5
1 |
SP1 decreases the amount of OTUD5. 1 / 1
1 |
biopax:msigdb
No evidence text available
SET affects OTUD5
1 |
SET binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
eidos
"d The level of ubiquitinated TRIM25 increased following OTUD5 depletion by siRNA in the Hep3B cells ."
32826889
RIPK1 affects OTUD5
| 1
RIPK1 activates OTUD5. 1 / 1
| 1
reach
"Meylan and colleagues have shown that RIP3 inhibits RIP1 by competition, down-regulating the TRIF–RIP1-induced NF-κB pathway.40 Similarly to DUBA, A20 is a de-ubiquitinating enzyme that has been found to act in the cytoplasm as a negative regulator of TLR responses, affecting RIP1 and TRAF6 and thereby terminating TLR-induced NF-κB signalling."
23909285
RING domain affects TRAF-C
| 1
OTUD5 binds RING domain and TRAF-C. 1 / 1
| 1
reach
"If DUBA binds to both TRAF-C and the catalytic RING domain of TRAF3, it impedes TRAF3 signaling not only by removing the Ub chains, but also by preventing its interactions.OTUB1 is also a debubiqutinase that targets TRAF3 after viral infection and attenuates virus-triggered IFN production [57]."
27208423
RABGEF1 affects OTUD5
1 |
RABGEF1 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
28514442
PML affects OTUD5
| 1
OTUD5 binds PML. 1 / 1
| 1
sparser
"Knocking down OTUD5 significantly inhibited the formation of PML-NBs, a finding that was consistent with the involvement of OTUD5 in the regulation of PML expression (Fig.  xref )."
32826889
PKLR affects OTUD5
1 |
OTUD5 binds PKLR. 1 / 1
1 |
biogrid
No evidence text available
19615732
PDCD5 affects TP53
| 1
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
PAX4 affects OTUD5
1 |
PAX4 decreases the amount of OTUD5. 1 / 1
1 |
biopax:msigdb
No evidence text available
OTUD5 affects ubiquitination
| 1
OTUD5 inhibits ubiquitination. 1 / 1
| 1
sparser
"The deubiquitinases OTUB1/2 [ xref , xref ], UCHL1 [ xref ], MYSM1 [ xref ] and DUBA [ xref ] inhibit K63-linked ubiquitination of TRAF3 or TRAF6 and negatively regulate IFNs production during viral infection."
29734366
OTUD5 affects ubiquitination ROR gammat
| 1
OTUD5 activates ubiquitination ROR gammat. 1 / 1
| 1
eidos
"Then , OTUD5 stabilizes UBR5 , causing ubiquitination of ROR gammat in mobilized T cells ( Rutz et al ., 2015 ) ."
32655987
OTUD5 affects tumorigenesis was
| 1
OTUD5 inhibits tumorigenesis was. 1 / 1
| 1
eidos
"Subsequently , we showed that TRIM25 blocked PML expression to promote cell proliferation and , potentially , tumorigenesis , which was prevented by OTUD5 , suggesting that OTUD5 functions by regulating the TRIM25 / PML axis ."
32826889
OTUD5 affects tumor necrosis factor receptor-associate
| 1
OTUD5 binds tumor necrosis factor receptor-associate. 1 / 1
| 1
reach
"DUBA directly binds tumor necrosis factor receptor-associate factor 3 (TRAF3) and cleaves its K63linked polyubiquitin chains, and its expression is suppressed during IL-1R1 stimulation [30] ."
| PMC
OTUD5 affects tumor necrosis factor receptor
| 1
OTUD5 binds tumor necrosis factor receptor. 1 / 1
| 1
reach
"DUBA bound tumor necrosis factor receptor associated factor 3 (TRAF3), an adaptor protein essential for the IFN-I response."
17991829
OTUD5 affects tumor growth
| 1
OTUD5 inhibits tumor growth. 1 / 1
| 1
eidos
"Importantly , OTUD5 knockdown accelerates tumor growth in a nude mouse model ."
32826889
OTUD5 affects transcriptional
| 1
OTUD5 inhibits transcriptional. 1 / 1
| 1
eidos
"OTUD5 inhibits transcriptional activity of TRIM25 by downregulating the ubiquitination level of TRIM25 but the question remains : how exactly does ubiquitination of TRIM25 relate to its functions ?"
32826889
OTUD5 affects transcriptional TRIM25
| 1
OTUD5 inhibits transcriptional TRIM25. 1 / 1
| 1
eidos
"Further investigation reveals that OTUD5 depletion leads to the enhanced transcriptional activity of TRIM25 and the inhibited expression of PML by altering the ubiquitination level of TRIM25 ."
32826889
reach
"The function of OTUD5 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent apoptosis in response to DNA damage stress."
24143256
OTUD5 affects stability p53 programmed cell death
| 1
OTUD5 activates stability p53 programmed cell death. 1 / 1
| 1
eidos
"OTU deubiquitinase 5 ( OTUD5 ) , a deubiquitinating enzyme , can enhance the stability of p53 and programmed cell death 5 ( PDCD5 ) , a protein related to the apoptosis , by deubiquitination ."
| PMC
reach
"Interferon type I (IFN-I) responses are triggered by pattern-recognition receptors (PRRs), and DUBA (OTUD5) was shown to negatively regulate this immune signaling pathway [29] ."
| PMC
OTUD5 affects resistance cells chemotherapeutic drugs
| 1
OTUD5 inhibits resistance cells chemotherapeutic drugs. 1 / 1
| 1
eidos
"In this study , it was found that the inhibition of OTUD5 could promote the resistance of NSCLC cells to chemotherapeutic drugs such as doxorubicin and cisplatin ."
| PMC
OTUD5 affects radiosensitivity cervical cancer cells
| 1
OTUD5 activates radiosensitivity cervical cancer cells. 1 / 1
| 1
eidos
"A recent study demonstrated that OTUD5 could increase the radiosensitivity of cervical cancer cells ( Yin et al ., 2019 ) , which was consistent with the results of this study ."
| PMC
OTUD5 affects protein stability STING
| 1
OTUD5 activates protein stability STING. 1 / 1
| 1
eidos
"Similarly , OTUD5 promotes the protein stability of STING via cleaving the K48-linked polyubiquitin chains ."
34707613
OTUD5 affects protein cells
| 1
OTUD5 activates protein cells. 1 / 1
| 1
eidos
"Western blot analysis demonstrated that the depletion of OTUD5 reduced the protein levels of PML in the Huh7 and Hep3B cells , a finding consistent with the RT-PCR results ( Fig. 6c ) , suggesting that OTUD5 is required for the regulation of PML at the transcription level ."
32826889
OTUD5 affects protein SFN
| 1
OTUD5 activates protein SFN. 1 / 1
| 1
eidos
"In addition , the ubiquitination level of MAVS was reduced following OTUD5 coexpression , and OTUD5 increased the protein level of SFN , demonstrating that OTUD5 was possibly involved in these signaling pathways to work with the TRIM25 E3 ubiquitin ligase in the protein complex ( Supplementary Fig. 5 ) ."
32826889
OTUD5 activates programmed cell death. 1 / 1
| 1
eidos
"Studies have shown that OTUD5 can activate the programmed cell death 5 ( PDCD5 , a tumor suppressor ; Park et al ., 2015 ) ."
| PMC
OTUD5 affects poly-ubiquitin chain
| 1
OTUD5 inhibits poly-ubiquitin chain. 1 / 1
| 1
reach
"Also known as DUBA (deubiquitinating enzyme A), the OTUD5 protein was shown to suppress type-I interferon (IFN-I) dependent innate immune response, by cleaving the poly-ubiquitin chain from the IFN-I adaptor protein, thus causing the disassociation of the adaptor from the downstream signaling complex, and ultimately the interruption of the IFN-I signaling cascade."
33675743
OTUD5 affects p53-PDCD5
| 1
OTUD5 binds p53-PDCD5. 1 / 1
| 1
reach
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination."
32655987
OTUD5 affects metastasis cells
| 1
OTUD5 inhibits metastasis cells. 1 / 1
| 1
eidos
"It was proved that OTUD5 inhibited the proliferation and metastasis of NSCLC cells but promoted their apoptosis via regulating p53 and PDCD5 ."
| PMC
OTUD5 affects metastasis NSCLC cells
| 1
OTUD5 inhibits metastasis NSCLC cells. 1 / 1
| 1
eidos
"The knockdown of OTUD5 inactivated p53 and PDCD5 , promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis ."
| PMC
OTUD5 affects metastasis NSCLC cell line HCC827
| 1
OTUD5 inhibits metastasis NSCLC cell line HCC827. 1 / 1
| 1
eidos
"In this study , it was demonstrated that OTUD5 impeded the proliferation and metastasis of the NSCLC cell line HCC827 via regulating PDCD5 expression ."
| PMC
OTUD5 affects maleate(2-)
| 1
OTUD5 activates maleate(2-). 1 / 1
| 1
reach
"Recently, a male specific multiple congenital anomaly disorder caused by pathogenic variants in OTUD5 was reported by two groups."
33748114
OTUD5 affects mTOR signaling pathway
| 1
OTUD5 activates mTOR signaling pathway. 1 / 1
| 1
eidos
"Here , we report that the deubiquitinating enzyme , ovarian tumor domain-containing protein 5 ( OTUD5 ) , can activate the mTOR signaling pathway , promote cancer progression , and show its oncogenic potential in bladder cancer ."
36085200
OTUD5 affects lys63-ubiquitination TRIM25
| 1
OTUD5 inhibits lys63-ubiquitination TRIM25. 1 / 1
| 1
eidos
"The results of the western blotting for the IPed protein showed that the OTUD5 knockdown significantly increased lys63-ubiquitination of TRIM25 ( Supplementary Fig. 3 ) ."
32826889
OTUD5 affects innate antiviral antitumor immunity
| 1
OTUD5 activates innate antiviral antitumor immunity. 1 / 1
| 1
eidos
"OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING ."
32879469
OTUD5 affects immune responses
| 1
OTUD5 activates immune responses. 1 / 1
| 1
eidos
"OTUD5 also modulates immune responses by deubiquitinating and stabilizing UBR5 to suppress the production of IL-17 and by selectively cleaving the polyubiquitin chains on TRAF3 to regulate IFN-I production17 ,18 ."
32826889
OTUD5 affects immune response
| 1
reach
"OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING."
32879469
OTUD5 affects enrichment TRIM25 PML
| 1
OTUD5 inhibits enrichment TRIM25 PML. 1 / 1
| 1
eidos
"Indeed , OTUD5 depletion increased the enrichment of TRIM25 on the promoter of PML ( Fig. 6a ) ."
32826889
OTUD5 affects efficient deubiquitination TRIM25
| 1
OTUD5 activates efficient deubiquitination TRIM25. 1 / 1
| 1
eidos
"In the in vitro deubiquitination assay , OTUD5 catalyzed the efficient deubiquitination of TRIM25 , and the TRIM25 deubiquitination required OTUD5 DUB activity , as indicated by the catalytically inactive OTUD5 ( OTUD5 / C224S ) failing to deubiquitinate TRIM25 ( Fig. 3b , c , lane 2 versus lane 5 ) ."
32826889
OTUD5 affects doxorubicin
| 1
OTUD5 inhibits doxorubicin. 1 / 1
| 1
reach
"OTUD5 knockdown also enhanced the resistance of NSCLC cells to doxorubicin and cisplatin."
32248621
OTUD5 activates double-strand break repair via nonhomologous end joining. 1 / 1
| 1
reach
"OTUD5 also stabilises Ku80, loss of OTUD5 reduces NHEJ repair efficiency [11] (Figure 2)."
31769469
OTUD5 affects colony lung carcinoma cells
| 1
OTUD5 inhibits colony lung carcinoma cells. 1 / 1
| 1
eidos
"a OTUD5 depletion promoted colony formation with lung carcinoma cells ."
32826889
OTUD5 affects cisplatin
| 1
OTUD5 inhibits cisplatin. 1 / 1
| 1
reach
"OTUD5 knockdown also enhanced the resistance of NSCLC cells to doxorubicin and cisplatin."
32248621
OTUD5 affects chemoradiotherapy resistance
| 1
OTUD5 inhibits chemoradiotherapy resistance. 1 / 1
| 1
eidos
"Since the FACT histone chaperone complex can promote the resistance of tumor cells to DNA damage factors ( Dejmek , Iglehart , & Lazaro , 2009 ; Koman et al ., 2012 ; Yarnell , Oh , Reinberg , & Lippard , 2001 ) , a follow-up research is necessary to determine whether OTUD5 can reduce chemoradiotherapy resistance by antagonizing the FACT histone chaperone complex ."
| PMC
OTUD5 affects caspase death
| 1
OTUD5 binds caspase death. 1 / 1
| 1
reach
"DUBA physically interacts with the initiator caspase death regulator Nedd2 like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye."
27518434
OTUD5 affects activation STING pathway
| 1
OTUD5 activates activation STING pathway. 1 / 1
| 1
eidos
"On the other hand , OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation , thus maintain the stability of STING and promote activation of STING pathway ( 87 ) ( 88 ) ( 89 ) ."
35603197
OTUD5 affects accessible chromatin neuroectodermal aberrant
| 1
OTUD5 activates accessible chromatin neuroectodermal aberrant. 1 / 1
| 1
eidos
"Loss of OTUD5 during differentiation leads to less accessible chromatin at neuroectodermal enhancers and aberrant gene expression ."
33523931
OTUD5 affects VARS1
1 |
VARS1 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
eidos
"Together , we provide novel insights into the pathogenesis of bladder cancer and first prove that OTUD5 can promote bladder cancer progression through the OTUD5-RNF186-sestrin2-mTOR axis , which may be exploited in the future for the diagnosis and treatment of this malignancy ."
36085200
OTUD5 affects Ubiquitination
| 1
eidos
"In response to genotoxic stress , OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( Luo , 2013 ; Park et al ., 2015 ) ."
32655987
OTUD5 affects USP11
1 |
USP11 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects TRIM35
1 |
TRIM35 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD5 affects TRAF5
1 |
OTUD5 deubiquitinates TRAF5. 1 / 1
1 |
ubibrowser
"Given that TRAF3 may be dispensable for RIG-I signalling?92, it cannot be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
24375678
OTUD5 affects TRAF3-TBK1 interaction
| 1
OTUD5 activates TRAF3-TBK1 interaction. 1 / 1
| 1
reach
"Indeed, DUBA and OTUD5, a DUB which selectively disassembles Lys63 linked ubiquitin chains on TRAF3, has been shown to suppress the production of type I interferon by reducing the level of TRAF3-TBK1 interaction XREF_BIBR."
28327663
OTUD5 affects TRAF2
1 |
OTUD5 deubiquitinates TRAF2. 1 / 1
1 |
ubibrowser
"Given that TRAF3 may be dispensable for RIG-I signalling?92, it cannot be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
24375678
OTUD5 affects TRAF-C
| 1
OTUD5 binds RING domain and TRAF-C. 1 / 1
| 1
reach
"If DUBA binds to both TRAF-C and the catalytic RING domain of TRAF3, it impedes TRAF3 signaling not only by removing the Ub chains, but also by preventing its interactions.OTUB1 is also a debubiqutinase that targets TRAF3 after viral infection and attenuates virus-triggered IFN production [57]."
27208423
OTUD5 affects TNFAIP3
1 |
TNFAIP3 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD5 affects TNF-α production
| 1
OTUD5 activates TNF-α production. 1 / 1
| 1
reach
"Up-regulation of OTUD5 further increased TNF-α production in LPMCs of IBD patients (160)."
34956195
OTUD5 affects TLR9
| 1
OTUD5 activates TLR9. 1 / 1
| 1
reach
"DUBA short interference RNA augmented the TLR9 dependent type I IFN response."
21115691
OTUD5 affects TGFB
| 1
OTUD5 inhibits TGFB. 1 / 1
| 1
reach
"For example, deubiquitinase DUBA can suppress RORgammat protein stability in TGF-beta stimulated Th17 cells [XREF_BIBR]."
| PMC
OTUD5 affects SUPT16H, and UBR5
| 1
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
OTUD5 affects SPT16
| 1
OTUD5 binds SPT16. 1 / 1
| 1
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
OTUD5 affects SET
1 |
SET binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects Rorgammat
| 1
OTUD5 decreases the amount of Rorgammat. 1 / 1
| 1
reach
"Consistently, T cell specific deletion of Duba in mice increased Th17 and moderately decreased Treg cell frequencies, but caused Rorgammat expression in some of the Treg cells."
29685903
OTUD5 affects RORgammat
| 1
OTUD5 decreases the amount of RORgammat. 1 / 1
| 1
reach
"Therefore, DUBA or UBR5 knockout can enhance the level of RORgammat and promote T H 17 cell differentiation."
32850399
OTUD5 affects RORgammat protein
| 1
OTUD5 inhibits RORgammat protein. 1 / 1
| 1
reach
"For example, deubiquitinase DUBA can suppress RORgammat protein stability in TGF-beta stimulated Th17 cells [XREF_BIBR]."
| PMC
OTUD5 affects RNAPII
| 1
OTUD5 inhibits RNAPII. 1 / 1
| 1
reach
"Furthermore, loss of the deubiquitylase OTUD5, which inhibits RNAPII elongation in response to DNA double-strand breaks , alleviates the sensitivity of ELOF1-KO cells to Illudin S, while its loss has the opposite impact on CSB-KO cells (Fig. 7a, b)."
34108663
OTUD5 affects RING domain, and TRAF-C
| 1
OTUD5 binds RING domain and TRAF-C. 1 / 1
| 1
reach
"If DUBA binds to both TRAF-C and the catalytic RING domain of TRAF3, it impedes TRAF3 signaling not only by removing the Ub chains, but also by preventing its interactions.OTUB1 is also a debubiqutinase that targets TRAF3 after viral infection and attenuates virus-triggered IFN production [57]."
27208423
OTUD5 affects RABGEF1
1 |
RABGEF1 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUD5 affects PML-NBs
| 1
OTUD5 activates PML-NBs. 1 / 1
| 1
eidos
"f Depletion of OTUD5 reduced the formation of PML-NBs in the Huh7 and Hep3B cells ."
32826889
OTUD5 affects PML altering ubiquitination
| 1
OTUD5 activates PML altering ubiquitination. 1 / 1
| 1
eidos
"Further investigation reveals that OTUD5 depletion leads to the enhanced transcriptional activity of TRIM25 and the inhibited expression of PML by altering the ubiquitination level of TRIM25 ."
32826889
OTUD5 affects PKLR
1 |
OTUD5 binds PKLR. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects PDCD5, and TP53
| 1
TP53 binds OTUD5 and PDCD5. 1 / 1
| 1
sparser
"In response to genotoxic stress, OTUD5 interacts with p53-PDCD5 to reduce its ubiquitination ( xref ; xref )."
32655987
reach
"On the other hand, over-expression of OTUD5 suppressed NSCLC cell proliferation, invasion, and migration."
35765958
OTUD5 affects NSCLC
| 1
OTUD5 inhibits NSCLC. 1 / 1
| 1
reach
"On the other hand, over-expression of OTUD5 suppressed NSCLC cell proliferation, invasion, and migration."
35765958
OTUD5 affects NMRAL1
| 1
NMRAL1 binds OTUD5. 1 / 1
| 1
reach
"HSCARG neither interacted with DUBA nor promoted its recruitment (XREF_SUPPLEMENTARY, B), and depletion of DUBA had no effect on HSCARG in inhibiting TRAF3 ubiquitination (XREF_SUPPLEMENTARY)."
24763515
OTUD5 affects MOV10
1 |
OTUD5 binds MOV10. 1 / 1
1 |
biogrid
No evidence text available
22658674
OTUD5 affects MDM2
| 1
OTUD5 deubiquitinates MDM2. 1 / 1
| 1
reach
"As shown in XREF_FIG, MDM2 can not be deubiquitinated by OTUD5."
24143256
OTUD5 affects LONRF2
1 |
LONRF2 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects LANCL2
1 |
OTUD5 binds LANCL2. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects K63-ub chains
| 1
OTUD5 activates K63-ub chains. 1 / 1
| 1
reach
"In line with this idea, the de-ubiquitinating enzyme A (DUBA) has been shown to directly interact with TRAF3 and mediate the removal of K63-ub chains."
21949557
OTUD5 affects K63-linked polyubiquitination AKT
| 1
OTUD5 inhibits K63-linked polyubiquitination AKT. 1 / 1
| 1
eidos
"DUB CYLD , OTUD5 and USP1 can reverse K63-linked polyubiquitination of AKT and inhibit its activation [ 85-87 ] ."
| PMC
OTUD5 affects K48-linked deubiquitination STING
| 1
OTUD5 activates K48-linked deubiquitination STING. 1 / 1
| 1
eidos
"On the other hand , OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation , thus maintain the stability of STING and promote activation of STING pathway ( 87 ) ( 88 ) ( 89 ) ."
35603197
OTUD5 affects K48
| 1
OTUD5 binds K48 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
OTUD5 affects IL6
| 1
OTUD5 inhibits IL6. 1 / 1
| 1
reach
"DUBA knockdown by siRNA transfection in Il1r1 -/- BMDCs (XREF_FIG) resulted in significantly increased IL-10 and IFN-beta production and decreased secretion of IL-6, but not TNF, in CpG stimulated Il1r1 -/- BMDCs (XREF_FIG)."
21115691
OTUD5 affects IKBKE
| 1
OTUD5 deubiquitinates IKBKE. 1 / 1
| 1
reach
"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
22017431
OTUD5 affects IGBP1
1 |
OTUD5 binds IGBP1. 1 / 1
1 |
biogrid
No evidence text available
22939629
OTUD5 affects IFNB1
| 1
OTUD5 activates IFNB1. 1 / 1
| 1
reach
"DUBA knockdown by siRNA transfection in Il1r1 -/- BMDCs (XREF_FIG) resulted in significantly increased IL-10 and IFN-beta production and decreased secretion of IL-6, but not TNF, in CpG stimulated Il1r1 -/- BMDCs (XREF_FIG)."
21115691
OTUD5 affects HES
| 1
OTUD5 inhibits HES. 1 / 1
| 1
reach
"To corroborate these results and exclude any off-target effects originating from clonal selection during iPSC reprogramming, we next generated control or OTUD5 depleted hES H1 cells and subjected them to neural conversion."
| PMC
OTUD5 affects GYS1
1 |
OTUD5 binds GYS1. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects GST
| 1
GST binds TP53 and OTUD5. 1 / 1
| 1
sparser
"As shown in xref , GST-p53 but not GST interacted with the full-length OTUD5."
24143256
OTUD5 affects GRB2
1 |
OTUD5 binds GRB2. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects GPX4
1 |
OTUD5 binds GPX4. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects FLNA
1 |
OTUD5 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects DUSP13
1 |
DUSP13 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
27432908
OTUD5 affects DNA repair
| 1
OTUD5 inhibits DNA repair. 1 / 1
| 1
eidos
"Studies have shown that OTUD5 could inhibit DNA damage repair by regulating the FACT histone chaperone complex ( de Vivo et al ., 2019 ) ."
| PMC
OTUD5 affects DNA break DSB repair
| 1
OTUD5 activates DNA break DSB repair. 1 / 1
| 1
eidos
"Our previous study indicated that OTUD5 promoted DNA double-strand break ( DSB ) repair by inhibiting Ku80 degradation14 ."
32826889
OTUD5 affects Caspase
| 1
Caspase binds OTUD5. 1 / 1
| 1
sparser
"DUBA physically interacts with the initiator caspase death regulator Nedd2-like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye."
27518434
eidos
"In order to study whether OTUD5 can inhibit NSCLC via regulating p53 expression , OTUD5 siRNA and a p53 overexpressing plasmid were used to construct an si-OTUD5 / p53 group , an si-OTUD5 group , a p53 group , and an si-NC group , respectively ."
| PMC
OTUD5 affects Carcinogenesis
| 1
OTUD5 inhibits Carcinogenesis. 1 / 1
| 1
eidos
"Our findings reveal a mechanism whereby OTUD5 regulates gene transcription and suppresses tumorigenesis by deubiquitinating TRIM25 , providing a potential target for oncotherapy ."
32826889
OTUD5 affects CTPS2
1 |
CTPS2 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects CASP2
| 1
CASP2 binds OTUD5. 1 / 1
| 1
reach
"DUBA physically interacts with the initiator caspase death regulator Nedd2 like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye."
27518434
OTUD5 affects CACYBP
1 |
OTUD5 binds CACYBP. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD5 affects ARPC3
1 |
OTUD5 binds ARPC3. 1 / 1
1 |
hprd
No evidence text available
16169070
NMRAL1 affects OTUD5
| 1
NMRAL1 binds OTUD5. 1 / 1
| 1
reach
"HSCARG neither interacted with DUBA nor promoted its recruitment (XREF_SUPPLEMENTARY, B), and depletion of DUBA had no effect on HSCARG in inhibiting TRAF3 ubiquitination (XREF_SUPPLEMENTARY)."
24763515
MTOR affects OTUD5
| 1
MTOR phosphorylates OTUD5. 1 / 1
| 1
sparser
"We also showed that mTOR directly phosphorylated OTUD5 and activated its DUB activity."
33110214
MOV10 affects OTUD5
1 |
OTUD5 binds MOV10. 1 / 1
1 |
biogrid
No evidence text available
22658674
MIR937 affects OTUD5
| 1
MIR937 inhibits OTUD5. 1 / 1
| 1
eidos
"Moreover , hsa-mir-137 , hsa-mir-1913 , hsa-mir-937 , hsa-mir-607 , hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5 ."
32655987
MIR607 affects OTUD5
| 1
MIR607 inhibits OTUD5. 1 / 1
| 1
eidos
"Moreover , hsa-mir-137 , hsa-mir-1913 , hsa-mir-937 , hsa-mir-607 , hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5 ."
32655987
MIR3149 affects OTUD5
| 1
MIR3149 inhibits OTUD5. 1 / 1
| 1
eidos
"Moreover , hsa-mir-137 , hsa-mir-1913 , hsa-mir-937 , hsa-mir-607 , hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5 ."
32655987
MIR1913 affects OTUD5
| 1
MIR1913 inhibits OTUD5. 1 / 1
| 1
eidos
"Moreover , hsa-mir-137 , hsa-mir-1913 , hsa-mir-937 , hsa-mir-607 , hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5 ."
32655987
MIR144 affects OTUD5
| 1
MIR144 inhibits OTUD5. 1 / 1
| 1
eidos
"Moreover , hsa-mir-137 , hsa-mir-1913 , hsa-mir-937 , hsa-mir-607 , hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5 ."
32655987
MIR137 affects OTUD5
| 1
MIR137 inhibits OTUD5. 1 / 1
| 1
eidos
"Moreover , hsa-mir-137 , hsa-mir-1913 , hsa-mir-937 , hsa-mir-607 , hsa-mir-3149 and hsa-mir-144 may inhibit the expression of OTUD5 ."
32655987
LONRF2 affects OTUD5
1 |
LONRF2 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
LEF1 affects OTUD5
1 |
LEF1 decreases the amount of OTUD5. 1 / 1
1 |
biopax:msigdb
No evidence text available
LANCL2 affects OTUD5
1 |
OTUD5 binds LANCL2. 1 / 1
1 |
biogrid
No evidence text available
19615732
K63 affects polyubiquitin chains
| 1
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
K63 affects TRAF3
| 1
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
K63 affects OTUD5, and polyubiquitin chains
| 1
OTUD5 binds K63 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
K63 affects OTUD5, and TRAF3
| 1
TRAF3 binds OTUD5 and K63. 1 / 1
| 1
reach
"DUBA interacts with TRAF3 and removes K63 polyubiquitin chains from TRAF3 in a manner that depends on its ubiquitin-interaction motif (UIM)."
19281271
K48 affects polyubiquitin chains
| 1
OTUD5 binds K48 and polyubiquitin chains. 1 / 1
| 1
reach
"Although the DUBA UIM domain binds both K48 and K63 polyubiquitin chains, DUBA specifically cleaves K63 polyubiquitin chains from TRAF3."
19217402
Interferon affects OTUD5
| 1
Interferon deubiquitinates OTUD5. 1 / 1
| 1
reach
"Several mechanisms dampen IFNα/β production, for example, deubiquitinating enzyme A (DUBA) is a negative regulator of IFNα/β downstream of multiple induction pathways [7]."
21281752
IL1R1 affects OTUD5
| 1
IL1R1 inhibits OTUD5. 1 / 1
| 1
reach
"DUBA knockdown by siRNA transfection in Il1r1 -/- BMDCs (XREF_FIG) resulted in significantly increased IL-10 and IFN-beta production and decreased secretion of IL-6, but not TNF, in CpG stimulated Il1r1 -/- BMDCs (XREF_FIG)."
21115691
IL1 affects OTUD5
| 1
IL1 activates OTUD5. 1 / 1
| 1
reach
"In other systems, IL-1 signaling has been shown to trigger the downregulation of deubiquitinating enzyme A (DUBA), which selectively cleaves K63 linked ubiquitin chains from TRAF3 to limit type I IFN responses."
29559569
IGBP1 affects OTUD5
1 |
OTUD5 binds IGBP1. 1 / 1
1 |
biogrid
No evidence text available
22939629
HDAC2 affects UBR5
| 1
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
Grape Seed Proanthocyanidins decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
24763279
GYS1 affects OTUD5
1 |
OTUD5 binds GYS1. 1 / 1
1 |
biogrid
No evidence text available
19615732
GST affects TP53
| 1
GST binds TP53 and OTUD5. 1 / 1
| 1
sparser
"As shown in xref , GST-p53 but not GST interacted with the full-length OTUD5."
24143256
GRB2 affects OTUD5
1 |
OTUD5 binds GRB2. 1 / 1
1 |
biogrid
No evidence text available
19615732
GPX4 affects OTUD5
1 |
OTUD5 binds GPX4. 1 / 1
1 |
biogrid
No evidence text available
19615732
FOXO4 affects OTUD5
1 |
FOXO4 decreases the amount of OTUD5. 1 / 1
1 |
biopax:msigdb
No evidence text available
FOXN1 affects OTUD5
1 |
FOXN1 decreases the amount of OTUD5. 1 / 1
1 |
biopax:msigdb
No evidence text available
FLNA affects OTUD5
1 |
OTUD5 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
19615732
E3_Ub_ligase affects OTUD5
| 1
sparser
"In order to test whether OTUD5 associates with an E3 ubiquitin ligase to regulate cell proliferation, the stable Flag-OTUD5/Hep3B cell line was established by transfecting Hep3B cells with plasmids expressing pCIN4-Flag-OTUD5 xref ."
32826889
Dietary Fats affects OTUD5
1 |
Dietary Fats increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
25016146
DUSP13 affects OTUD5
1 |
DUSP13 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
27432908
Caspase affects OTUD5
| 1
Caspase binds OTUD5. 1 / 1
| 1
sparser
"DUBA physically interacts with the initiator caspase death regulator Nedd2-like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye."
27518434
CTPS2 affects OTUD5
1 |
CTPS2 binds OTUD5. 1 / 1
1 |
biogrid
No evidence text available
19615732
CSNK2A1 affects OTUD5
1 |
CSNK2A1 phosphorylates OTUD5 on S177. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
CK2 affects OTUD5
| 1
CK2 phosphorylates OTUD5 on S177. 1 / 1
| 1
sparser
"OTUD5 purified from E. coli is inactive, but can be activated when the Ser177 residue of OTUD5 is phosphorylated by CKII instead of by mimic phosphorylation ( xref ; xref )."
34177595
CD4+ affects OTUD5
| 1
CD4+ inhibits OTUD5. 1 / 1
| 1
reach
"Exposure of Bach2 silenced CD4+ T-lymphocytes to CP tissue extract showed increased Ahr, decreased OTUD5, and enhanced Th17 cell differentiation."
29511557
CASP2 affects OTUD5
| 1
CASP2 binds OTUD5. 1 / 1
| 1
reach
"DUBA physically interacts with the initiator caspase death regulator Nedd2 like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye."
27518434
CACYBP affects OTUD5
1 |
OTUD5 binds CACYBP. 1 / 1
1 |
biogrid
No evidence text available
19615732
BPTF affects OTUD5
1 |
BPTF decreases the amount of OTUD5. 1 / 1
1 |
biopax:msigdb
No evidence text available
Aroclor 1254 affects OTUD5
1 |
Aroclor 1254 decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
23650126
AZM551248 affects OTUD5
1 |
AZM551248 increases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
22323515
ARPC3 affects OTUD5
1 |
OTUD5 binds ARPC3. 1 / 1
1 |
hprd
No evidence text available
16169070
(+)-catechin affects OTUD5
1 |
(+)-catechin decreases the amount of OTUD5. 1 / 1
1 |
ctd
No evidence text available
24763279