IndraLab

Statements

OTUD5 deubiquitinates TRAF3. 12 / 14
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"However, it is uncertain whether DUBA also deubiquitinates TRAF3 in rainbow trout through a similar mechanism."
38670412
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"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."
21625535
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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKepsilon XREF_BIBR."
23333767
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"Furthermore, OTUD5 deubiquitylates TRAF3 resulting in diminished type I interferon and interleukin-10 responses [XREF_BIBR]."
25972356
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"Indeed, the blockade of DUBA-mediated deubiquitination of TRAF3 by DUBA-specific siRNA cancelled the negative regulatory effects of NOD2 on DSS-induced colitis in mice treated with CpG, and mice treated with DUBA-siRNA displayed severe DSS-induced colitis even after repeated MDP injections (67, 68)."
39403381
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"Two close relatives of DUBA, OTUB1 and OTUB2, were shown to reduce TRAF3 ubiquitination coupled with decreased anti-viral signaling responses in Sendai virus infected HEK 293T cells."
22017431
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
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"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
22017431
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"DUBA deubiquitinates TRAF3 to down-regulate its interaction with TBK1 and consequent activation of IRF-3."
27178468
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"In fact, DUBA physically interacts with TRAF3 and inhibits the self-ubiquitination of TRAF3."
19146978
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"Interestingly, the newly identified cellular DUB, DUBA, inhibits the ubiquitination of TRAF3, an adaptor of RIG-I signaling, and negatively regulates the type I IFN signaling pathway ."
18957937
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"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3."
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