IndraLab

Statements

OTUD5 deubiquitinates TRAF3. 14 / 14
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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKɛ [38]."
23333767
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"Two close relatives of DUBA, OTUB1 and OTUB2, were shown to reduce TRAF3 ubiquitination coupled with decreased anti-viral signaling responses in Sendai virus infected HEK 293T cells."
22017431
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"DUBA deubiquitinates TRAF3 to downregulate its interaction with TBK1 and consequent activation of IRF-3 (Kayagaki et al., 2007)."
27178468
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"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3."
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"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."
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"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3 (Kayagaki et al., 2007; Wang et al., 2011)."
24622840
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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKe [38] ."
23333767
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"DUBA deubiquitinates TRAF3 to down-regulate its interaction with TBK1 and consequent activation of IRF-3."
27178468
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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKepsilon XREF_BIBR."
23333767
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"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
22017431
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"Interestingly, the newly identified cellular DUB, DUBA, inhibits the ubiquitination of TRAF3, an adaptor of RIG-I signaling, and negatively regulates the type I IFN signaling pathway 21."
18957937
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"DUBA is an OUT domaincontaining DUB that deubiquitinates TRAF3 and inhibits TLR3and RLRs-mediated activation of IRF3 [93] ."
25651846
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"Furthermore, OTUD5 deubiquitylates TRAF3 resulting in diminished type I interferon and interleukin-10 responses [XREF_BIBR]."
25972356
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"Interestingly, the newly identified cellular DUB, DUBA, inhibits the ubiquitination of TRAF3, an adaptor of RIG-I signaling, and negatively regulates the type I IFN signaling pathway ."
18957937