IndraLab

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OTUD5 activates double-strand break repair via nonhomologous end joining. 3 / 3
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"OTUD5 promotes NHEJ repair by increasing the stability of Ku80 [52] (Figure 2E)."
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"This suggests the possibility that OTUD5 is directly phosphorylated by ATM to function as an amplifier of ATM-dependent DDR signaling in a potential positive-feedback circuit, resembling its role in mTOR signaling.In the context of DNA repair, OTUD5 has been suggested to promote NHEJ by counteracting the degradation of Ku80, a core NHEJ factor, in certain cell lines ."
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"OTUD5 also stabilises Ku80, loss of OTUD5 reduces NHEJ repair efficiency [11] (Figure 2)."
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