IndraLab

Statements

OTUD5 activates STING1. 5 / 5
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"25 OTUD5 enhanced anti‐viral infection and anti‐tumor immunity by stabilizing STING."
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"In the innate immune response, OTUD5 can promote the stability of STING [37]."
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"Together, these results suggest that USP11/OTUD5 axis induces RILI through stabilizing STING in endothelial cells [74]."
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"Similarly, OTUD5 promotes the protein stability of STING via cleaving the K48-linked polyubiquitin chains."
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"On the other hand, OTUD5 and USP20 catalyze the K48-linked deubiquitination of STING and inhibit STING degradation, thus maintain the stability of STING and promote activation of STING pathway (87–89)."
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