IndraLab

Statements

OTUD5 is phosphorylated on S177. 7 / 13
4 | 7 2
sparser
"Phosphorylation of OTUD5 (also known as DUBA) at Ser177 is both necessary and sufficient to activate the enzyme which is a negative regulator of type I interferon [ xref ]."
32512887
sparser
"Phosphorylation of OTUD5 at S177 is an absolute requirement for DUB activity because pS177 acts as a lynchpin that locks together two helices that are disordered in the unphosphorylated state."
34813758
sparser
"The phosphorylation of OTUD5 at Ser177 is required for the activation of the enzyme."
37190070
sparser
"In the OTU family, phosphorylation of DUBA (OTUD5) on S177 results in activation of its enzymatic activity ( xref )."
25904330
sparser
"A nuclear magnetic resonance (NMR) analysis revealed that the phosphorylation of Ser177 alone does not induce significant structural changes, and only after binding ubiquitin does Ser177-phosphorylated OTUD5 show significant structural changes that activate its enzymatic activity."
37190070
sparser
"Phosphorylation of OTUD5 at Ser177 is critical to the enzyme activity of OTUD526.in our results, the most important of kinase-target networks related primarily to the kinases PLK1, ATM, PIK3CA, CDK5 and CHEK1."
32655987
sparser
"In response to TCR stimulation, the protein levels of the Ser177-phosphorylated OTUD5 were found to be upregulated."
37190070