IndraLab

Statements

OTUD5 binds TP53. 22 / 34
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"Taken together, these results provide clinical evidence for p53‐OTUD5 axis‐mediated regulation of GPX4 protein stability, suggesting that the expression level of OTUD5 is important for ferroptosis of gastric cancer cells."
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"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
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"Since OTUD5 was shown to interact with p53, we also performed mapping analysis of the interaction between OTUD5 and p53."
25499082
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"However, upon prolonged genotoxic stress, the interaction between OTUD5 and PDCD5 was reduced, while the association between OTUD5 and p53 gradually increased, leading to p53 induction ( Fig. 4A )."
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"OTUD5 can bind to TP53 and regulate its ubiquitination levels [ xref ]."
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"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
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"OTUD5 can bind to TP53 and regulate its ubiquitination levels [56]."
37190070
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"Since OTUD5 was shown to interact with p53, we also performed mapping analysis of the interaction between OTUD5 and p53."
25499082
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"OTUD5 forms a direct complex with p53 and controls level of ubiquitination."
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"P53 interacts with OTUD5."
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"Among them, one clone encoding OTUD5, as confirmed by sequencing, was found to be a novel p53 interacting protein ( xref ), consistent with proteomic studies by the Harper Laboratory[ xref ] that suggested an interaction of p53 with OTUD5."
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"Next, the interaction between p53 and OTUD5 in mammalian cells was verified by co-immunoprecipitation (Co-IP) assay."
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"These results demonstrate that p53 interacts with OTUD5 specifically in mammalian cells."
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"Furthermore, we sought to determine whether endogenous p53 interacts with endogenous OTUD5."
24143256
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"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
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"Therefore, OTUD5 protein interacts with p53."
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"P53 interacts with OTUD5."
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"Next, the interaction between p53 and OTUD5 in mammalian cells was verified by co-immunoprecipitation (Co-IP) assay."
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"These results demonstrate that p53 interacts with OTUD5 specifically in mammalian cells."
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"Furthermore, we sought to determine whether endogenous p53 interacts with endogenous OTUD5."
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"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
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"To determine whether p53 directly regulates OTUD5, ChIP‐qPCR experiment was performed and results showed that p53 could bind to the OTUD5 promoter region (Figure xref )."
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