IndraLab

Statements

OTUD5 binds TP53. 32 / 35
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sparser
"Wild-type p53 directly binds to the OTUD5 gene promoter and inhibits its transcription, leading to a loss of OTUD5 protein expression."
41315060
sparser
"Taken together, these results provide clinical evidence for p53‐OTUD5 axis‐mediated regulation of GPX4 protein stability, suggesting that the expression level of OTUD5 is important for ferroptosis of gastric cancer cells."
40070026
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"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
reach
"Since OTUD5 was shown to interact with p53, we also performed mapping analysis of the interaction between OTUD5 and p53."
25499082
reach
"However, upon prolonged genotoxic stress, the interaction between OTUD5 and PDCD5 was reduced, while the association between OTUD5 and p53 gradually increased, leading to p53 induction ( Fig. 4A )."
25499082
biogrid
No evidence text available
25499082
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25499082
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25499082
sparser
"OTUD5 can bind to TP53 and regulate its ubiquitination levels [ xref ]."
37190070
biogrid
No evidence text available
24143256
biogrid
No evidence text available
24143256
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24143256
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"Next, the interaction between p53 and OTUD5 in mammalian cells was verified by co-immunoprecipitation (Co-IP) assay."
24143256
biogrid
No evidence text available
24143256
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No evidence text available
24143256
sparser
"A recent study showed that in case of stress, programmed cell death 5 (PDCD5) is required to promote the interaction between OTUD5 and p53."
29479529
reach
"OTUD5 can bind to TP53 and regulate its ubiquitination levels [56]."
37190070
sparser
"Since OTUD5 was shown to interact with p53, we also performed mapping analysis of the interaction between OTUD5 and p53."
25499082
sparser
"OTUD5 forms a direct complex with p53 and controls level of ubiquitination."
24143256
sparser
"P53 interacts with OTUD5."
24143256
sparser
"Among them, one clone encoding OTUD5, as confirmed by sequencing, was found to be a novel p53 interacting protein ( xref ), consistent with proteomic studies by the Harper Laboratory[ xref ] that suggested an interaction of p53 with OTUD5."
24143256
sparser
"Next, the interaction between p53 and OTUD5 in mammalian cells was verified by co-immunoprecipitation (Co-IP) assay."
24143256
sparser
"These results demonstrate that p53 interacts with OTUD5 specifically in mammalian cells."
24143256
sparser
"Furthermore, we sought to determine whether endogenous p53 interacts with endogenous OTUD5."
24143256
sparser
"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
sparser
"Therefore, OTUD5 protein interacts with p53."
24143256
reach
"P53 interacts with OTUD5."
24143256
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"These results demonstrate that p53 interacts with OTUD5 specifically in mammalian cells."
24143256
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"Furthermore, we sought to determine whether endogenous p53 interacts with endogenous OTUD5."
24143256
reach
"Besides, the direct interaction between OTUD5 and p53 was performed by a GST pull-down assay."
24143256
biogrid
No evidence text available
19615732
sparser
"To determine whether p53 directly regulates OTUD5, ChIP‐qPCR experiment was performed and results showed that p53 could bind to the OTUD5 promoter region (Figure xref )."
40070026