IndraLab

Statements

UBR5 binds OTUD5. 8 / 8
| 5 3
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"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
sparser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
reach
"OTUD5 localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis."
30508113
sparser
"First, OTUD5 interacts with UBR5 and represses RNA Pol II-mediated elongation and RNA synthesis."
32268558
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"The OTUD5 and UBR5 complex regulates FACT mediated transcription at damaged chromatin."
30508113
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
sparser
"Mass spectrometry coupled to short interfering RNA (siRNA) screening of ubiquitinated proteins in Duba −/− Th17 cells revealed that DUBA directly bound and deubiquitinated UBR5 (Ubiquitin protein ligase E3 component n-recognin 5)."
34635393