IndraLab

Statements

reach
"The function of OTUD5 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent apoptosis in response to DNA damage stress."
24143256
reach
"Using RNAi, we found that certain deubiquitinases, BAP1, USP14 and OTUD5 each promote proviral transcription."
37523412
reach
"We found that OTUD5, and its binding partner UBR5, are modulators of transcription-induced replication fork stress."
37713620
reach
"21 In addition, OTUD5 promotes DNA damage repair by inhibiting Ku80 degradation or regulating FACT‐dependent transcription at damaged chromatin."
37552043
reach
"Using the ROC curve and Kaplan–Meier method, OTUD5 was demonstrated as an interesting biomarker for predicting HBeAg seroconversion.In summary, we revealed that deubiquitinase OTUD5 could positively regulate HBV transcription and replication in HepG2.2.15 cells by deubiquitinating the K48-mediated ubiquitination of hepatitis B precore/core components to promote HBV infection."
37897511
reach
"OTUD5 promoted HBV transcription and replication."
37897511