IndraLab

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OTUD5 binds RING domain and TRAF-C. 1 / 1
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"If DUBA binds to both TRAF-C and the catalytic RING domain of TRAF3, it impedes TRAF3 signaling not only by removing the Ub chains, but also by preventing its interactions.OTUB1 is also a debubiqutinase that targets TRAF3 after viral infection and attenuates virus-triggered IFN production [57]."