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OTUD5 deubiquitinates TRAF2. 3 / 3
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"We found that K63-ubiquitylation of TRAF2 was increased by OTUD5 knockdown and decreased by TRIP12 knockdown (Fig. 3h)."
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"Given that TRAF3 may be dispensable for RIG-I signalling 92, it cannot be excluded, however, that <span class="match term0">DUBA</span> also targets other E3 ligases like <span class="match term1">TRAF2</span>, 5 and 6."
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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