 
            IndraLab
Statements
OTUD5 inhibits signal transduction. 2 / 2
                        
    
      
      
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
        
      
      
    
      
      
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                                  "Using an inhibitor of ERK1/2, we demonstrated OTUD5 inhibited ERK1/2 MAPK signaling pathway to accumulate HNF4α expression to benefit HBV replication.In this study, the healthy cohort, HBV carriers and chronic hepatitis B patients were enrolled, the expression OTUD5 in different groups was analyzed, and significant differences of OTUD5 were observed between the HBV-negative cohort and HBV positive carriers, meaning the expression of OTUD5 in human serum was promoted by infecting hepatitis B virus."