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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUD5 inhibits poly-ubiquitin chain. 1 / 1

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"Also known as DUBA (deubiquitinating enzyme A), the OTUD5 protein was shown to suppress type-I interferon (IFN-I) dependent innate immune response, by cleaving the poly-ubiquitin chain from the IFN-I adaptor protein, thus causing the disassociation of the adaptor from the downstream signaling complex, and ultimately the interruption of the IFN-I signaling cascade."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...