IndraLab

Statements

OTUD5 inhibits cell population proliferation. 9 / 9
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"Consistently, overexpression of OTUD5 promoted the proliferation, while OTUD5 depletion suppressed the proliferation of gastric cancer cells (Figure 3O,P)."
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"These data collectively support the notion that OTUD5 inhibits the proliferation of gastric cancer cells.2.4 Wild-type p53 transcriptionally suppresses OTUD5 to promote ferroptosis in gastric cancer cells."
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"On the other hand, over-expression of OTUD5 suppressed NSCLC cell proliferation, invasion, and migration."
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"In addition, OTUD5 knockdown has been shown to inhibit the proliferation of cancer cell lines with mutations that activate the mTOR pathway; these include HT29 colon cancer cells and MCF7 breast cancer cells [10]."
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"Overexpression of OTUD5 suppresses NSCLC cell proliferation, invasion, and migration."
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"Overall, these findings suggested that overexpression of OTUD5 suppressed NSCLC cell proliferation, invasion, and migration."
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"We treated control and OTUD5‐KO cells with nutlin‐3a and observed that knockout of OTUD5, in combination with nutlin‐3a treatment, led to a reduction in protein levels of OTUD5 and GPX4 (Figure 5A,B), thereby triggering ferroptosis in cancer cells and consequently inhibiting cell proliferation (Figure 5C,D)."
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"Li et al. found that OTUD5 stabilizes PTEN through deubiquitination and that the overexpression of OTUD5 inhibits NSCLC cell proliferation, invasion and migration [9] (Figure 3E)."
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"Two different lung tumor cell lines , H1299 and A549 , were used to investigate whether siRNA-mediated depletion of OTUD5 also promoted cell proliferation ."
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