IndraLab

Statements

OTUD5 activates PDCD5. 5 / 8
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"Studies have shown that OTUD5 can activate the programmed cell death 5 (PDCD5, a tumor suppressor; Park et al., xref )."
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"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
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"Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress."
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"OTU deubiquitinase (OTUD5) binds to PDCD5inresponseto etoposide treatment and effectively mediates the sequential activation of both PDCD5 and P53."
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"Overexpression of OTUD5 efficiently enhanced the activation of both PDCD5 and p53."
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