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OTUD5 activates PDCD5. 14 / 17
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"Importantly, we found that OTUD5 promotes the p53 pathway in a PDCD5-dependent manner."
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"Accordingly, OTUD5 overexpression has been shown to effectively enhance the activation of PDCD5 and TP53."
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"This sequential interplay between OTUD5 and either PDCD5 or p53 was abolished by knockdown of either OTUD5 or PDCD5 ( Fig. 4B , second and third panel), suggesting that PDCD5 stabilization by OTUD5 pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, OTUD5 and YAF2 promote the TP53 signal pathway in a PDCD5-dependent manner, highlighting the critical role of the PDCD5 network, which acts as a central hub in the regulation of genotoxic s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
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"Moreover, we showed that OTUD5 mediated the sequential activation of PDCD5 and p53 in response to genotoxic stress."
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"Because overexpression of OTUD5 increased the PDCD5 stability via its UIM motif, we also investigated whether OTUD5 increased PDCD5 stability by deubiquitinating PDCD5."
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"By both in situ PLA and immunoprecipitation assays, we demonstrated that knockdown of OTUD5 eliminated the induction of PDCD5 at the early stage of the DNA damage response and failed to induce the p53[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Treatment with MG132 efficiently increased PDCD5 levels; whereas, knockdown of OTUD5 greatly diminished the effect of MG132 on the stabilization of PDCD5, indicating that OTUD5 played a critical role [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A time-course experiment with cycloheximide (CHX) treatment showed that OTUD5 WT enhanced PDCD5 stability; however, inactive mutant OTUD5 C224S failed to increase the stability of PDCD5 ( Fig. 2B )."
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"OTU deubiquitinase (OTUD5) binds to PDCD5inresponseto etoposide treatment and effectively mediates the sequential activation of both PDCD5 and P53."
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"Studies have shown that OTUD5 can activate the programmed cell death 5 (PDCD5, a tumor suppressor; Park et al., xref )."
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"These data demonstrated that OTUD5 mediated sequential activation of PDCD5 and p53 in response to genotoxic stress.We further validated our findings using PDCD5- depleted mouse embryonic fibroblast (M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUD5 can increase the stability of TP53 and PDCD5 through deubiquitination [22] (Figure 3D)."
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