IndraLab

Statements

OTUD5 inhibits XRCC5. 3 / 3
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"21 In addition, OTUD5 promotes DNA damage repair by inhibiting Ku80 degradation or regulating FACT‐dependent transcription at damaged chromatin."
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"This suggests the possibility that OTUD5 is directly phosphorylated by ATM to function as an amplifier of ATM-dependent DDR signaling in a potential positive-feedback circuit, resembling its role in mTOR signaling.In the context of DNA repair, OTUD5 has been suggested to promote NHEJ by counteracting the degradation of Ku80, a core NHEJ factor, in certain cell lines ."
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"OTUD5 also stabilises Ku80, loss of OTUD5 reduces NHEJ repair efficiency [11] (Figure 2)."
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