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OTUD5 deubiquitinates PDCD5. 3 / 4
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"Because overexpression of OTUD5 increased the PDCD5 stability via its UIM motif, we also investigated whether OTUD5 increased PDCD5 stability by deubiquitinating PDCD5."
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"Strikingly, wild-type OTUD5 efficiently reduced the ubiquitination of PDCD5 when compared with the inactive mutant OTUD5 C224S ( Fig. 2D ), while knockdown of OTUD5 increased the ubiquitination of PDC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We also observed that OTUD5 robustly reduced the ubiquitination of PDCD5 when compared to overexpression of other deubiquitinating enzymes, indicating the selective action of OTUD5 on PDCD5 ubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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