IndraLab

Statements

OTUD5 activates cell differentiation. 3 / 3
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"Intriguingly, this separation-of-function mutant (OTUD5 DeltaCterm) failed to support neural crest differentiation and showed aberrant CNS precursor formation (XREF_FIG and fig."
| PMC
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"Previous research has demonstrated that the ability of OTUD5 to cleave K48‐ubiquitin chains is required to support differentiation and that, during embryonic development, OTUD5 regulates cell fate decisions by cleaving the degrading K48‐ubiquitin junctions of a substrate (Beck et al., 2021; Park et al., 2015; Yin et al., 2019)."
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"Thus, OTUD5 controls neural cell fate commitment by regulating chromatin accessibility at neural- and neural crest specific enhancers to enable activation of transcriptional networks that drive the differentiation program."
| PMC