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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

IL-1RI decreases the amount of OTUD5. 2 / 2

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"Consistent with the protein data, Duba mRNA levels were increased in freshly isolated splenocytes and mesenteric LN derived cells from Il1r1 -/- mice (XREF_FIG), suggesting that IL-1RI signaling negatively regulates DUBA transcription."

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"We show that IL-1RI signaling down-regulates the expression of deubiquitinating enzyme A (DUBA) and consequently enhances the Lys63 linked ubiquitination of TNF receptor associated factor 3 (TRAF3), which is necessary for the transcription of antiinflammatory cytokines."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...