IndraLab

Statements

OTUD5 inhibits Interferon. 12 / 13
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"Indeed, DUBA and OTUD5, a DUB which selectively disassembles Lys63 linked ubiquitin chains on TRAF3, has been shown to suppress the production of type I interferon by reducing the level of TRAF3-TBK1 interaction XREF_BIBR."
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"Since DUBA is known to negatively regulate type I IFN and IFN is associated with IBD, it is important to understand association of DUBA and IBD as well."
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"OTUD5 (DUBA) is activated by phosphorylation ( Huang et al., 2012 ) and suppresses the type I interferon response by cleaving the polyubiquitin chain from tumor necrosis factor receptor-associated fac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the study showing that OTUD5 suppresses the type I interferon (IFN-1) production, the proposed mechanism is that OTUD5 antagonizes the TRAF3 signaling (21)."
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"The activation of TLR4 and TLR3 stimulates the K 63 -linked ubiquitination of TRAF3, which is required for the activation of IRF3 and the production of type I IFNs, and DUBA removes K 63 -linked ubiquitin chains from TRAF3, thereby inhibiting type I IFN responses."
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"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I and MDA5-mediated IFN induction."
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"Thus, DUBA mediated inhibition of TRF3 inhibition blocks TLR-dependent type 1 IFN production, but does not inhibit NF-κB activation [86] ."
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"OTUD5 has been shown to suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein."
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"It has been demonstrated that the deubiquitinating enzymes A20 and CYLD inhibit NF-kappaB signaling by targeting TRAF6 upstream of IKK, while the deubiquitinating protein DUBA inhibits type I interferon activity by targeting TRAF3."
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"For example, deubiquitinating enzyme A (DUBA) is able to negatively regulate the interferon response induced by PRRs to maintain homeostasis (Kayagaki et al., 2007)."
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"DUBA inhibits type I IFN production in the absence of IL-1RI signaling."
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"The deubiquitinating enzyme A (DUBA), a novel OTU-domain DUB has been shown to negatively regulate IFN signaling following RIG-I, MDA-5 or TLR3 stimulation [60] ."
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