IndraLab

Statements

OTUD5 inhibits Interferon. 8 / 9
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"DUBA inhibits type I IFN production in the absence of IL-1RI signaling."
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"OTUD5 has been shown to suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein."
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"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I and MDA5-mediated IFN induction."
28717359
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"They showed that reducing the expression of DUBA augments the IFN response to poly(I:C) whereas ectopic expression of DUBA blocks the IFN response."
22312431
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"It has been demonstrated that the deubiquitinating enzymes A20 and CYLD inhibit NF-kappaB signaling by targeting TRAF6 upstream of IKK, while the deubiquitinating protein DUBA inhibits type I interferon activity by targeting TRAF3."
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"For example, DUBA, a member of the Otubain (OTUB) family, has been shown to deubiquitinate TRAF3 and negatively regulate TLR3- and RIG-I/MDA5-mediated IFN induction (52)."
28717359
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"The activation of TLR4 and TLR3 stimulates the K 63 -linked ubiquitination of TRAF3, which is required for the activation of IRF3 and the production of type I IFNs, and DUBA removes K 63 -linked ubiquitin chains from TRAF3, thereby inhibiting type I IFN responses."
23674823
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"Indeed, DUBA and OTUD5, a DUB which selectively disassembles Lys63 linked ubiquitin chains on TRAF3, has been shown to suppress the production of type I interferon by reducing the level of TRAF3-TBK1 interaction XREF_BIBR."
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