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Lipopolysaccharide activates OTUD5. 3 / 3
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"As DUBA protein is also increased in macrophages by LPS stimulation, it may also function as part of a negative feedback circuit."
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"As OTUD5 is induced by LPS stimulation , it might act as a negative feedback regulator of IFN signaling by targeting TRAF3 [ 119 ] ."
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"As DUBA protein is also increased in macrophages by LPS stimulation, it may also function as part of a negative feedback circuit.Another OTU DUB family protein, the tumor suppressor, CYLD, has been identified as a negative regulator of RIG-I by two groups [61, 62] ."
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