IndraLab

Statements

OTUD5 deubiquitinates UBR5. 2 / 2
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"When DUBA deubiquitylates UBR5 and rescues it from degradation, UBR5 is free to polyubiquitylate RORgammaT, driving its degradation and consequently limiting Th17 differentiation."
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ubibrowser
"<span class="match term0">DUBA</span> interacted with the ubiquitin ligase <span class="match term1">UBR5</span>, which suppressed <span class="match term0">DUBA</span> abundance in naive T cells. <span class="match term0">DUBA</span> accumulated in activated T cells and stabilized <span class="match term1">UBR5</span>, which then ubiquitylated RORgammat in response to TGF-beta signalling. "
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