IndraLab

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OTUD5 deubiquitinates TP53. 11 / 12
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"In this study, we provide new evidences that OTUD5 can also function to deubiquitinate and stabilize p53."
24143256
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"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay and found thatMDM2 can not be deubiquitinated by OTUD5 (XREF_FIG)."
24143256
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"These data indicate that both PDCD5 and OTUD5 are required for p53-mediated apoptosis in response to genotoxic stress.Previous work has shown that OTUD5 stabilizes p53 via deubiquitination of p53 [16][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25499082
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"Other DUBs, OTUD1 and OTUD5, are also involved in the deubiquitination and stabilization of TP53 in response to DNA damage stress in U2OS cells [51,52]."
36551253
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"Besides, OTUB1 and OTUD5 are also discovered to positively regulate p53 stability by deubiquitinating p53 [8] [9] ."
28807825
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"OTU deubiquitinase 5 (OTUD5) can also deubiquitinate p53 protein and stabilize it, thus affecting apoptosis that is induced by DNA damage [38]."
36613989
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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."
29142505
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"We show that (1) OTUD5 is a novel p53 interacting protein; (2) OTUD5 deubiquitinates p53, leading to the stabilization of p53; (3) OTUD5 can help in the stabilization and activation of p53 in response to DNA damage; (4) OTUD5 is required for p53 induced apoptosis in response to DNA damage."
24143256
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"Another DUB, OTUD5, interacts and deubiquitylates p53 in response to DNA damage stress."
27516771
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"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay."
24143256
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"Overall, OTUD5 deubiquitinates p53, leading to the stabilization of p53."
24143256