IndraLab

Statements

OTUD5 deubiquitinates TP53. 8 / 8
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"In this study, we provide new evidences that OTUD5 can also function to deubiquitinate and stabilize p53."
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"Review"
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"We show that (1) OTUD5 is a novel p53 interacting protein; (2) OTUD5 deubiquitinates p53, leading to the stabilization of p53; (3) OTUD5 can help in the stabilization and activation of p53 in response to DNA damage; (4) OTUD5 is required for p53 induced apoptosis in response to DNA damage."
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"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay."
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"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay and found thatMDM2 can not be deubiquitinated by OTUD5 (XREF_FIG)."
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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."
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"Overall, OTUD5 deubiquitinates p53, leading to the stabilization of p53."
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"Another DUB, OTUD5, interacts and deubiquitylates p53 in response to DNA damage stress."
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