IndraLab

Statements


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sparser
"TRAF3-DUBA interaction."

sparser
"xref shows the TRAF3-DUBA interaction model that we obtained by PRISM xref , xref , xref , in which the concave crevice on TRAF-C of TRAF3 is in contact with DUBA."

reach
"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."

sparser
"DUBA physically binds with TRAF3 that is an E3 ubiquitin ligase and could assemble lysine-63–linked polyubiquitin chains [ 8 ]."

reach
"Interestingly, DUBA physically interacts with TRAF3 and inhibits the self ubiquitylation of TRAF3 (XREF_FIG)."

sparser
"Interaction of endogenous TRAF3 and DUBA takes place upon TLR3 stimulation ( 70 )."

sparser
"There are no clinically observed oncogenic mutations on DUBA that fall onto DUBA-TRAF3 interface residues or nonsense/frameshift mutations."

sparser
"In fact, DUBA physically interacts with TRAF3 and inhibits the self-ubiquitination of TRAF3."

sparser
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197] ."

sparser
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197] ."
| DOI

reach
"DUBA physically binds with TRAF3 that is an E3 ubiquitin ligase and could assemble lysine-63–linked polyubiquitin chains [ 8 ]."

reach
"As previous studies have reported that DUBA could bind with TRAF3 [ 7 , 8 ] we thus further explored the expression patterns of TRAF3 in spleen upon poly(I:C) stimulation."

sparser
"Interestingly, DUBA physically interacts with TRAF3 and inhibits the self-ubiquitylation of TRAF3 (Ref. xref ) ( xref )."

reach
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197] ."

sparser
"DUBA interacts with TRAF3 and specifically cleaves the K63-linked polyubiquitin chains, dissociating TRAF3 from the downstream signaling complex containing TBK1, thereby suppressing the production of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"DUBA not only interacts with TRAF3 and inhibits TRAF3 ubiquitination, but also interrupts the interaction between TRAF3 and TBK1."

reach
"DUBA binds to TRAF3, an adaptor protein essential for induction of type I IFN responses, as described above, to selectively cleave K63-linked polyubiquitin chains on TRAF3 (Fig. 1)."

sparser
"As a positive control, the Co-IP analysis of HEK293T cells and PMs revealed that OTUD5 interacts with TRAF3 both exogenously and endogenously (Fig.  xref )."

reach
"The interaction between DUBA and TRAF3 occurs during TLR3 activation [197]."
| DOI