IndraLab
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"Meylan and colleagues have shown that RIP3 inhibits RIP1 by competition, down-regulating the TRIF–RIP1-induced NF-κB pathway.40 Similarly to DUBA, A20 is a de-ubiquitinating enzyme that has been found to act in the cytoplasm as a negative regulator of TLR responses, affecting RIP1 and TRAF6 and thereby terminating TLR-induced NF-κB signalling."