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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RIPK1 activates OTUD5. 1 / 1

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"Meylan and colleagues have shown that RIP3 inhibits RIP1 by competition, down-regulating the TRIF–RIP1-induced NF-κB pathway.40 Similarly to DUBA, A20 is a de-ubiquitinating enzyme that has been found to act in the cytoplasm as a negative regulator of TLR responses, affecting RIP1 and TRAF6 and thereby terminating TLR-induced NF-κB signalling."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...