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PDCD5 activates OTUD5. 4 / 4
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"Conversely, PDCD5 knockdown greatly attenuated the effect of OTUD5 on TP53 activation."
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"Therefore , it was concluded that OTUD5 could impede the proliferation , migration , and invasion of HCC827 cells while facilitating their apoptosis , and the role of OTUD5 was partly mediated by PDCD5 ."
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"Although OTUD5 enhanced ET-induced PDCD5 stabilization and p53 activation, genetic depletion of PDCD5 reversed the positive action of OTUD5 on PDCD5 stabilization ( Fig. 5A )."
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"Conversely, reintroduction of PDCD5 in PDCD5 −/− MEF cells dramatically restored OTUD5 WT function in promoting p53 activation."
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